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Short disordered termini and proline-rich domain are major regulators of UBQLN1/2/4 phase separation.
Biophys J. 2023 Nov 30:S0006-3495(23)04117-6. doi: 10.1016/j.bpj.2023.11.3401. Online ahead of print.
Biophys J. 2023.
PMID: 38041404
Free article.
Previously uncharacterized interactions between the folded and intrinsically disordered domains impart asymmetric effects on UBQLN2 phase separation.
Zheng T, Galagedera SKK, Castañeda CA.
Zheng T, et al. Among authors: galagedera skk.
Protein Sci. 2021 Jul;30(7):1467-1481. doi: 10.1002/pro.4128. Epub 2021 Jun 5.
Protein Sci. 2021.
PMID: 34029402
Free PMC article.
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Decoding optimal ligand design for multicomponent condensates.
Galagedera SKK, Dao TP, Enos SE, Chaudhuri A, Schmit JD, Castañeda CA.
Galagedera SKK, et al.
bioRxiv [Preprint]. 2023 Apr 25:2023.03.13.532222. doi: 10.1101/2023.03.13.532222.
bioRxiv. 2023.
PMID: 36993708
Free PMC article.
Updated.
Preprint.
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Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4.
Dao TP, Rajendran A, Galagedera SKK, Haws W, Castañeda CA.
Dao TP, et al. Among authors: galagedera skk.
bioRxiv [Preprint]. 2023 Sep 29:2023.09.27.559790. doi: 10.1101/2023.09.27.559790.
bioRxiv. 2023.
PMID: 37808720
Free PMC article.
Updated.
Preprint.
Item in Clipboard
Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units.
Galagedera SKK, Dao TP, Enos SE, Chaudhuri A, Schmit JD, Castañeda CA.
Galagedera SKK, et al.
Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2306638120. doi: 10.1073/pnas.2306638120. Epub 2023 Oct 12.
Proc Natl Acad Sci U S A. 2023.
PMID: 37824531
Free PMC article.
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Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate.
Valentino IM, Llivicota-Guaman JG, Dao TP, Mulvey EO, Lehman AM, Galagedera SKK, Mallon EL, Castañeda CA, Kraut DA.
Valentino IM, et al. Among authors: galagedera skk.
bioRxiv [Preprint]. 2024 Mar 21:2024.03.15.585243. doi: 10.1101/2024.03.15.585243.
bioRxiv. 2024.
PMID: 38559018
Free PMC article.
Preprint.
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