Al-Karmalawy AA - Search Results

1

A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments.

Hefny SM, El-Moselhy TF, El-Din N, Ammara A, Angeli A, Ferraroni M, El-Dessouki AM, Shaldam MA, Yahya G, Al-Karmalawy AA, Supuran CT, Tawfik HO. Hefny SM, et al. Among authors: al karmalawy aa. Eur J Med Chem. 2024 May 24;274:116527. doi: 10.1016/j.ejmech.2024.116527. Online ahead of print. Eur J Med Chem. 2024. PMID: 38810335

2

Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations.

Tawfik HO, Mousa MHA, Zaky MY, El-Dessouki AM, Sharaky M, Abdullah O, El-Hamamsy MH, Al-Karmalawy AA. Tawfik HO, et al. Among authors: al karmalawy aa. Bioorg Chem. 2024 May 21;149:107483. doi: 10.1016/j.bioorg.2024.107483. Online ahead of print. Bioorg Chem. 2024. PMID: 38805913

3

Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment.

Abdel-Motaal M, Aldakhili DA, Abo Elmaaty A, Sharaky M, Mourad MAE, Alzahrani AYA, Mohamed NA, Al-Karmalawy AA. Abdel-Motaal M, et al. Among authors: al karmalawy aa. Drug Dev Res. 2024 Jun;85(4):e22197. doi: 10.1002/ddr.22197. Drug Dev Res. 2024. PMID: 38751223

4

Spirulina versus metformin for controlling some insulin signaling pathway genes in induced polycystic ovary syndrome rat model.

El Leithy AA, Abozaid M, Al-Karmalawy AA, Mahmoud Allam R, Nourelden AZ, Amer RM, Abd El Azeem NH, Abo-Zeid FS. El Leithy AA, et al. Among authors: al karmalawy aa. Gene. 2024 May 11;921:148524. doi: 10.1016/j.gene.2024.148524. Online ahead of print. Gene. 2024. PMID: 38735598

5

Rational design, synthesis, biological evaluation, and molecular modeling of novel naphthamide derivatives possessing potent, reversible, and competitive inhibitory mode of action over human monoamine oxidase.

Elkamhawy A, Oh JM, Kim M, El-Halaby LO, Abdellattif MH, Al-Karmalawy AA, Kim H, Lee K. Elkamhawy A, et al. Among authors: al karmalawy aa. Mol Divers. 2024 May 10. doi: 10.1007/s11030-024-10841-9. Online ahead of print. Mol Divers. 2024. PMID: 38727994

6

Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice.

Antar SA, Abdo W, Helal AI, Abduh MS, Hakami ZH, Germoush MO, Alsulimani A, Al-Noshokaty TM, El-Dessouki AM, ElMahdy MK, Elgebaly HA, Al-Karmalawy AA, Mahmoud AM. Antar SA, et al. Among authors: al karmalawy aa. Life Sci. 2024 Jul 1;348:122688. doi: 10.1016/j.lfs.2024.122688. Epub 2024 May 4. Life Sci. 2024. PMID: 38710284

7

Identification of Ureidocoumarin-Based Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors via Drug Repurposing Approach, Biological Evaluation, and In Silico Studies.

El-Damasy AK, Kim HJ, Al-Karmalawy AA, Alnajjar R, Khalifa MM, Bang EK, Keum G. El-Damasy AK, et al. Among authors: al karmalawy aa. Pharmaceuticals (Basel). 2024 Mar 27;17(4):427. doi: 10.3390/ph17040427. Pharmaceuticals (Basel). 2024. PMID: 38675389 Free PMC article.

8

LC/MS-Based Metabolomics Reveals Chemical Variations of Two Broccoli Varieties in Relation to Their Anticholinesterase Activity: In vitro and In silico Studies.

Ibrahim RM, El-Shiekh RA, Mohamed OG, Al-Karmalawy AA, Tripathi A, Abdel-Baki PM. Ibrahim RM, et al. Among authors: al karmalawy aa. Plant Foods Hum Nutr. 2024 Apr 12. doi: 10.1007/s11130-024-01161-2. Online ahead of print. Plant Foods Hum Nutr. 2024. PMID: 38607508

9

Throat spray formulated with virucidal pharmaceutical excipients as an effective early prophylactic or treatment strategy against pharyngitis post-exposure to SARS-CoV-2.

Boseila AA, Ghareeb AZ, AbdElwahab MG, Seadawy MG, Al-Karmalawy AA, Yassa NW, Ghareeb DA. Boseila AA, et al. Among authors: al karmalawy aa. Eur J Pharm Biopharm. 2024 Jun;199:114279. doi: 10.1016/j.ejpb.2024.114279. Epub 2024 Apr 7. Eur J Pharm Biopharm. 2024. PMID: 38588829

10

Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.

Abdelrahman NA, Al-Karmalawy AA, Jaballah MY, Yahya G, Sharaky M, Abouzid KAM. Abdelrahman NA, et al. Among authors: al karmalawy aa. RSC Med Chem. 2024 Feb 6;15(3):981-997. doi: 10.1039/d3md00751k. eCollection 2024 Mar 20. RSC Med Chem. 2024. PMID: 38516606

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