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Page 1
Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains.
McCulloch LH, Sambasivam V, Hughes AL, Annaluru N, Ramalingam S, Fanfani V, Lobzaev E, Mitchell LA, Cai J; Build-A-Genome Class; Jiang H, LaCava J, Taylor MS, Bishai WR, Stracquadanio G, Steinmetz LM, Bader JS, Zhang W, Boeke JD, Chandrasegaran S. McCulloch LH, et al. Among authors: bader js. Cell Genom. 2023 Nov 9;3(11):100419. doi: 10.1016/j.xgen.2023.100419. eCollection 2023 Nov 8. Cell Genom. 2023. PMID: 38020974 Free PMC article.
Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics.
Blount BA, Lu X, Driessen MRM, Jovicevic D, Sanchez MI, Ciurkot K, Zhao Y, Lauer S, McKiernan RM, Gowers GF, Sweeney F, Fanfani V, Lobzaev E, Palacios-Flores K, Walker RSK, Hesketh A, Cai J, Oliver SG, Cai Y, Stracquadanio G, Mitchell LA, Bader JS, Boeke JD, Ellis T. Blount BA, et al. Among authors: bader js. Cell Genom. 2023 Nov 9;3(11):100418. doi: 10.1016/j.xgen.2023.100418. eCollection 2023 Nov 8. Cell Genom. 2023. PMID: 38020971 Free PMC article.
A DNA integrity network in the yeast Saccharomyces cerevisiae.
Pan X, Ye P, Yuan DS, Wang X, Bader JS, Boeke JD. Pan X, et al. Among authors: bader js. Cell. 2006 Mar 10;124(5):1069-81. doi: 10.1016/j.cell.2005.12.036. Epub 2006 Feb 16. Cell. 2006. PMID: 16487579 Free article.
Design of a synthetic yeast genome.
Richardson SM, Mitchell LA, Stracquadanio G, Yang K, Dymond JS, DiCarlo JE, Lee D, Huang CL, Chandrasegaran S, Cai Y, Boeke JD, Bader JS. Richardson SM, et al. Among authors: bader js. Science. 2017 Mar 10;355(6329):1040-1044. doi: 10.1126/science.aaf4557. Science. 2017. PMID: 28280199
Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions.
Zhao Y, Coelho C, Hughes AL, Lazar-Stefanita L, Yang S, Brooks AN, Walker RSK, Zhang W, Lauer S, Hernandez C, Cai J, Mitchell LA, Agmon N, Shen Y, Sall J, Fanfani V, Jalan A, Rivera J, Liang FX, Bader JS, Stracquadanio G, Steinmetz LM, Cai Y, Boeke JD. Zhao Y, et al. Among authors: bader js. Cell. 2023 Nov 22;186(24):5220-5236.e16. doi: 10.1016/j.cell.2023.09.025. Epub 2023 Nov 8. Cell. 2023. PMID: 37944511 Free article.
Manipulating the 3D organization of the largest synthetic yeast chromosome.
Zhang W, Lazar-Stefanita L, Yamashita H, Shen MJ, Mitchell LA, Kurasawa H, Lobzaev E, Fanfani V, Haase MAB, Sun X, Jiang Q, Goldberg GW, Ichikawa DM, Lauer SL, McCulloch LH, Easo N, Lin SJ, Camellato BR, Zhu Y, Cai J, Xu Z, Zhao Y, Sacasa M; Build-A-Genome Class; Noyes MB, Bader JS, Deutsch S, Stracquadanio G, Aizawa Y, Dai J, Boeke JD. Zhang W, et al. Among authors: bader js. Mol Cell. 2023 Dec 7;83(23):4424-4437.e5. doi: 10.1016/j.molcel.2023.10.015. Epub 2023 Nov 8. Mol Cell. 2023. PMID: 37944526 Free article.
Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function.
Luo J, Vale-Silva LA, Raghavan AR, Mercy G, Heldrich J, Sun X, Li MK, Zhang W, Agmon N, Yang K, Cai J, Stracquadanio G, Thierry A, Zhao Y, Coelho C, McCulloch LH, Lauer S; Build-A-Genome Class; Kaback DB, Bader JS, Mitchell LA, Mozziconacci J, Koszul R, Hochwagen A, Boeke JD. Luo J, et al. Among authors: bader js. Cell Genom. 2023 Nov 9;3(11):100439. doi: 10.1016/j.xgen.2023.100439. eCollection 2023 Nov 8. Cell Genom. 2023. PMID: 38020967 Free PMC article.
Context-dependent neocentromere activity in synthetic yeast chromosome VIII.
Lauer S, Luo J, Lazar-Stefanita L, Zhang W, McCulloch LH, Fanfani V, Lobzaev E, Haase MAB, Easo N, Zhao Y, Yu F, Cai J; Build-A-Genome Class; Bader JS, Stracquadanio G, Boeke JD. Lauer S, et al. Among authors: bader js. Cell Genom. 2023 Nov 9;3(11):100437. doi: 10.1016/j.xgen.2023.100437. eCollection 2023 Nov 8. Cell Genom. 2023. PMID: 38020969 Free PMC article.
Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration.
Foo JL, Kitano S, Susanto AV, Jin Z, Lin Y, Luo Z, Huang L, Liang Z, Mitchell LA, Yang K, Wong A, Cai Y, Cai J, Stracquadanio G, Bader JS, Boeke JD, Dai J, Chang MW. Foo JL, et al. Among authors: bader js. Cell Genom. 2023 Nov 9;3(11):100435. doi: 10.1016/j.xgen.2023.100435. eCollection 2023 Nov 8. Cell Genom. 2023. PMID: 38020970 Free PMC article.
Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects.
Williams TC, Kroukamp H, Xu X, Wightman ELI, Llorente B, Borneman AR, Carpenter AC, Van Wyk N, Meier F, Collier TRV, Espinosa MI, Daniel EL, Walker RSK, Cai Y, Nevalainen HKM, Curach NC, Deveson IW, Mercer TR, Johnson DL, Mitchell LA, Bader JS, Stracquadanio G, Boeke JD, Goold HD, Pretorius IS, Paulsen IT. Williams TC, et al. Among authors: bader js. Cell Genom. 2023 Nov 9;3(11):100379. doi: 10.1016/j.xgen.2023.100379. eCollection 2023 Nov 8. Cell Genom. 2023. PMID: 38020977 Free PMC article.
142 results