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A novel peanut allergy immunotherapy: Plant-based enveloped Ara h 2 Bioparticles activate dendritic cells and polarize T cell responses to Th1.
Castenmiller C, Nagy NA, Kroon PZ, Auger L, Desgagnés R, Martel C, Mirande L, Morel B, Roberge J, Stordeur V, Tropper G, Vézina LP, van Ree R, Gomord V, de Jong EC. Castenmiller C, et al. Among authors: roberge j. World Allergy Organ J. 2023 Nov 10;16(11):100839. doi: 10.1016/j.waojou.2023.100839. eCollection 2023 Nov. World Allergy Organ J. 2023. PMID: 38020282 Free PMC article.
Plant-based enveloped Ara h 2 bioparticles display exceptional hypo-allergenicity.
Castenmiller C, Stigler M, Kirpas ME, Versteeg S, Akkerdaas JH, Pena-Castellanos G, Blokhuis BR, Dreskin SC, Auger L, Desgagnés R, Martel C, Mirande L, Morel B, Roberge J, Stordeur V, Tropper G, Vézina LP, Gomord V, de Jong EC, Redegeld F, Shreffler WG, Aglas L, van Ree R. Castenmiller C, et al. Among authors: roberge j. Clin Exp Allergy. 2023 May;53(5):577-581. doi: 10.1111/cea.14294. Epub 2023 Feb 13. Clin Exp Allergy. 2023. PMID: 36779573 Free PMC article. No abstract available.
Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
Gilleran JA, Ashraf K, Delvillar M, Eck T, Fondekar R, Miller EB, Hutchinson A, Dong A, Seitova A, De Souza ML, Augeri D, Halabelian L, Siekierka J, Rotella DP, Gordon J, Childers WE, Grier MC, Staker BL, Roberge JY, Bhanot P. Gilleran JA, et al. Among authors: roberge jy. J Med Chem. 2024 Mar 14;67(5):3467-3503. doi: 10.1021/acs.jmedchem.3c01795. Epub 2024 Feb 19. J Med Chem. 2024. PMID: 38372781
Structure-based design and optimization of a new class of small molecule inhibitors targeting the P-stalk binding pocket of ricin.
Rudolph MJ, Dutta A, Tsymbal AM, McLaughlin JE, Chen Y, Davis SA, Theodorous SA, Pierce M, Algava B, Zhang X, Szekely Z, Roberge JY, Li XP, Tumer NE. Rudolph MJ, et al. Among authors: roberge jy. Bioorg Med Chem. 2024 Feb 15;100:117614. doi: 10.1016/j.bmc.2024.117614. Epub 2024 Feb 5. Bioorg Med Chem. 2024. PMID: 38340640 Free article.
Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo.
Kulhankova K, Traore S, Cheng X, Benk-Fortin H, Hallée S, Harvey M, Roberge J, Couture F, Kohli S, Gross TJ, Meyerholz DK, Rettig GR, Thommandru B, Kurgan G, Wohlford-Lenane C, Hartigan-O'Connor DJ, Yates BP, Newby GA, Liu DR, Tarantal AF, Guay D, McCray PB Jr. Kulhankova K, et al. Among authors: roberge j. Nat Commun. 2023 Dec 5;14(1):8051. doi: 10.1038/s41467-023-43904-w. Nat Commun. 2023. PMID: 38052872 Free PMC article.
Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells In Vivo.
Kulhankova K, Traore S, Cheng X, Benk-Fortin H, Hallée S, Harvey M, Roberge J, Couture F, Gross T, Newby G, Liu D, Tarantal A, Guay D, McCray P Jr. Kulhankova K, et al. Among authors: roberge j. Res Sq [Preprint]. 2023 Feb 17:rs.3.rs-2540755. doi: 10.21203/rs.3.rs-2540755/v1. Res Sq. 2023. PMID: 36824928 Free PMC article. Updated. Preprint.
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.
Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Das Pradhan A, et al. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5. N Engl J Med. 2022. PMID: 36342113 Clinical Trial.
90 results