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GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders.
López-Tobón A, Shyti R, Villa CE, Cheroni C, Fuentes-Bravo P, Trattaro S, Caporale N, Troglio F, Tenderini E, Mihailovich M, Skaros A, Gibson WT, Cuomo A, Bonaldi T, Mercurio C, Varasi M, Osborne L, Testa G. López-Tobón A, et al. Among authors: mercurio c. Sci Adv. 2023 Dec;9(48):eadh2726. doi: 10.1126/sciadv.adh2726. Epub 2023 Nov 29. Sci Adv. 2023. PMID: 38019906 Free PMC article.
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.
Cavallo F, Troglio F, Fagà G, Fancelli D, Shyti R, Trattaro S, Zanella M, D'Agostino G, Hughes JM, Cera MR, Pasi M, Gabriele M, Lazzarin M, Mihailovich M, Kooy F, Rosa A, Mercurio C, Varasi M, Testa G. Cavallo F, et al. Among authors: mercurio c. Mol Autism. 2020 Nov 19;11(1):88. doi: 10.1186/s13229-020-00387-6. Mol Autism. 2020. PMID: 33208191 Free PMC article.
New targets to modulate the DNA damage response.
Mercurio C, Varasi M. Mercurio C, et al. Future Med Chem. 2018 Oct;10(20):2377-2380. doi: 10.4155/fmc-2018-0231. Epub 2018 Oct 16. Future Med Chem. 2018. PMID: 30325211 No abstract available.
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
Ravasio R, Ceccacci E, Nicosia L, Hosseini A, Rossi PL, Barozzi I, Fornasari L, Zuffo RD, Valente S, Fioravanti R, Mercurio C, Varasi M, Mattevi A, Mai A, Pavesi G, Bonaldi T, Minucci S. Ravasio R, et al. Among authors: mercurio c. Sci Adv. 2020 Apr 8;6(15):eaax2746. doi: 10.1126/sciadv.aax2746. eCollection 2020 Apr. Sci Adv. 2020. PMID: 32284990 Free PMC article.
LSD1-directed therapy affects glioblastoma tumorigenicity by deregulating the protective ATF4-dependent integrated stress response.
Faletti S, Osti D, Ceccacci E, Richichi C, Costanza B, Nicosia L, Noberini R, Marotta G, Furia L, Faretta MR, Brambillasca S, Quarto M, Bertero L, Boldorini R, Pollo B, Gandini S, Cora D, Minucci S, Mercurio C, Varasi M, Bonaldi T, Pelicci G. Faletti S, et al. Among authors: mercurio c. Sci Transl Med. 2021 Dec 8;13(623):eabf7036. doi: 10.1126/scitranslmed.abf7036. Epub 2021 Dec 8. Sci Transl Med. 2021. PMID: 34878824
Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.
Fioravanti R, Romanelli A, Mautone N, Di Bello E, Rovere A, Corinti D, Zwergel C, Valente S, Rotili D, Botrugno OA, Dessanti P, Vultaggio S, Vianello P, Cappa A, Binda C, Mattevi A, Minucci S, Mercurio C, Varasi M, Mai A. Fioravanti R, et al. Among authors: mercurio c. ChemMedChem. 2020 Apr 3;15(7):643-658. doi: 10.1002/cmdc.201900730. Epub 2020 Feb 14. ChemMedChem. 2020. PMID: 32003940 Free PMC article.
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
Sartori L, Mercurio C, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Villa M, Vultaggio S, Botrugno OA, Dessanti P, Minucci S, Zagarrí E, Carettoni D, Iuzzolino L, Varasi M, Vianello P. Sartori L, et al. Among authors: mercurio c. J Med Chem. 2017 Mar 9;60(5):1673-1692. doi: 10.1021/acs.jmedchem.6b01018. Epub 2017 Feb 27. J Med Chem. 2017. PMID: 28186755
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
Vianello P, Sartori L, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Villa M, Botrugno OA, Dessanti P, Minucci S, Vultaggio S, Zagarrí E, Varasi M, Mercurio C. Vianello P, et al. Among authors: mercurio c. J Med Chem. 2017 Mar 9;60(5):1693-1715. doi: 10.1021/acs.jmedchem.6b01019. Epub 2017 Feb 27. J Med Chem. 2017. PMID: 28186757
75 results