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USP19 deubiquitinase inactivation regulates α-synuclein ubiquitination and inhibits accumulation of Lewy body-like aggregates in mice.
Schorova L, Bedard N, Khayachi A, Ho HH, Bolivar-Pedroso J, Huynh J, Piccirelli M, Wang Y, Plourde M, Luo W, Del Cid-Pellitero E, Shlaifer I, Castellanos-Montiel MJ, Yu Z, Valenzuela DVC, Lacalle-Aurioles M, Kriz A, Ye Y, Durcan TM, Wing SS. Schorova L, et al. Among authors: luo w. NPJ Parkinsons Dis. 2023 Nov 28;9(1):157. doi: 10.1038/s41531-023-00601-1. NPJ Parkinsons Dis. 2023. PMID: 38017009 Free PMC article.
Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation.
Tavassoly O, Del Cid Pellitero E, Larroquette F, Cai E, Thomas RA, Soubannier V, Luo W, Durcan TM, Fon EA. Tavassoly O, et al. Among authors: luo w. Neurotherapeutics. 2021 Apr;18(2):979-997. doi: 10.1007/s13311-021-01017-6. Epub 2021 Mar 12. Neurotherapeutics. 2021. PMID: 33713002 Free PMC article.
Co-registration of Imaging Modalities (MRI, CT and PET) to Perform Frameless Stereotaxic Robotic Injections in the Common Marmoset.
Kwan C, Kang MS, Nuara SG, Gourdon JC, Bédard D, Tardif CL, Hopewell R, Ross K, Bdair H, Hamadjida A, Massarweh G, Soucy JP, Luo W, Del Cid Pellitero E, Shlaifer I, Durcan TM, Fon EA, Rosa-Neto P, Frey S, Huot P. Kwan C, et al. Among authors: luo w. Neuroscience. 2022 Jan 1;480:143-154. doi: 10.1016/j.neuroscience.2021.11.009. Epub 2021 Nov 11. Neuroscience. 2022. PMID: 34774970
A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease.
Bérard M, Sheta R, Malvaut S, Rodriguez-Aller R, Teixeira M, Idi W, Turmel R, Alpaugh M, Dubois M, Dahmene M, Salesse C, Lamontagne-Proulx J, St-Pierre MK, Tavassoly O, Luo W, Del Cid-Pellitero E, Qazi R, Jeong JW, Durcan TM, Vallières L, Tremblay ME, Soulet D, Lévesque M, Cicchetti F, Fon EA, Saghatelyan A, Oueslati A. Bérard M, et al. Among authors: luo w. PLoS Biol. 2022 Mar 9;20(3):e3001578. doi: 10.1371/journal.pbio.3001578. eCollection 2022 Mar. PLoS Biol. 2022. PMID: 35263320 Free PMC article.
Rapid macropinocytic transfer of α-synuclein to lysosomes.
Bayati A, Banks E, Han C, Luo W, Reintsch WE, Zorca CE, Shlaifer I, Del Cid Pellitero E, Vanderperre B, McBride HM, Fon EA, Durcan TM, McPherson PS. Bayati A, et al. Among authors: luo w. Cell Rep. 2022 Jul 19;40(3):111102. doi: 10.1016/j.celrep.2022.111102. Cell Rep. 2022. PMID: 35858558 Free article.
Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.
Lackie RE, de Miranda AS, Lim MP, Novikov V, Madrer N, Karunatilleke NC, Rutledge BS, Tullo S, Brickenden A, Maitland MER, Greenberg D, Gallino D, Luo W, Attaran A, Shlaifer I, Del Cid Pellitero E, Schild-Poulter C, Durcan TM, Fon EA, Duennwald M, Beraldo FH, Chakravarty MM, Bussey TJ, Saksida LM, Soreq H, Choy WY, Prado VF, Prado MAM. Lackie RE, et al. Among authors: luo w. Acta Neuropathol. 2022 Nov;144(5):881-910. doi: 10.1007/s00401-022-02491-8. Epub 2022 Sep 19. Acta Neuropathol. 2022. PMID: 36121476 Free PMC article.
MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.
Dorion MF, Yaqubi M, Senkevich K, Kieran NW, MacDonald A, Chen CXQ, Luo W, Wallis A, Shlaifer I, Hall JA, Dudley RWR, Glass IA; Birth Defects Research Laboratory; Stratton JA, Fon EA, Bartels T, Antel JP, Gan-Or Z, Durcan TM, Healy LM. Dorion MF, et al. Among authors: luo w. Brain. 2024 Feb 1;147(2):427-443. doi: 10.1093/brain/awad298. Brain. 2024. PMID: 37671615 Free PMC article.
Neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms.
Tullo S, Miranda AS, Del Cid-Pellitero E, Lim MP, Gallino D, Attaran A, Patel R, Novikov V, Park M, Beraldo FH, Luo W, Shlaifer I, Durcan TM, Bussey TJ, Saksida LM, Fon EA, Prado VF, Prado MAM, Chakravarty MM. Tullo S, et al. Among authors: luo w. J Neurochem. 2023 Oct 7. doi: 10.1111/jnc.15967. Online ahead of print. J Neurochem. 2023. PMID: 37804203
8,049 results