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Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
Spiwoková P, Horn M, Fanfrlík J, Jílková A, Fajtová P, Leontovyč A, Houštecká R, Bieliková L, Brynda J, Chanová M, Mertlíková-Kaiserová H, Caro-Diaz EJE, Almaliti J, El-Sakkary N, Gerwick WH, Caffrey CR, Mareš M. Spiwoková P, et al. Among authors: caffrey cr. ACS Infect Dis. 2024 May 17. doi: 10.1021/acsinfecdis.3c00589. Online ahead of print. ACS Infect Dis. 2024. PMID: 38757505
Development of subunit selective proteasome substrates for Schistosoma species.
Jiang Z, Silva EB, Liu C, Fajtová P, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ. Jiang Z, et al. Among authors: caffrey cr. bioRxiv [Preprint]. 2024 Feb 14:2024.02.13.580161. doi: 10.1101/2024.02.13.580161. bioRxiv. 2024. PMID: 38405969 Free PMC article. Preprint.
Biomechanics of parasite migration within hosts.
Yeh YT, Del Álamo JC, Caffrey CR. Yeh YT, et al. Among authors: caffrey cr. Trends Parasitol. 2024 Feb;40(2):164-175. doi: 10.1016/j.pt.2023.12.001. Epub 2024 Jan 2. Trends Parasitol. 2024. PMID: 38172015 Review.
Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors.
Francisco KR, Bruystens J, Varricchio C, McCurdy S, Wu J, Lopez-Ramirez MA, Ginsberg M, Caffrey CR, Brancale A, Gingras AR, Hixon MS, Ballatore C. Francisco KR, et al. Among authors: caffrey cr. ACS Pharmacol Transl Sci. 2023 Oct 9;6(11):1651-1658. doi: 10.1021/acsptsci.3c00156. eCollection 2023 Nov 10. ACS Pharmacol Transl Sci. 2023. PMID: 37974623 Free article.
Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis.
Monti L, Liu LJ, Varricchio C, Lucero B, Alle T, Yang W, Bem-Shalom I, Gilson M, Brunden KR, Brancale A, Caffrey CR, Ballatore C. Monti L, et al. Among authors: caffrey cr. ChemMedChem. 2023 Oct 17;18(20):e202300193. doi: 10.1002/cmdc.202300193. Epub 2023 Jul 24. ChemMedChem. 2023. PMID: 37429821
220 results