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Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis.
James EA, Holers VM, Iyer R, Prideaux EB, Rao NL, Rims C, Muir VS, Posso SE, Bloom MS, Zia A, Elliott SE, Adamska JZ, Ai R, Brewer RC, Seifert JA, Moss L, Barzideh S, Demoruelle MK, Striebich CC, Okamoto Y, Sainbayar E, Crook AA, Peterson RA, Vanderlinden LA, Wang W, Boyle DL, Robinson WH, Buckner JH, Firestein GS, Deane KD. James EA, et al. Among authors: bloom ms. Nat Commun. 2023 Nov 22;14(1):7637. doi: 10.1038/s41467-023-43091-8. Nat Commun. 2023. PMID: 37993439 Free PMC article.
B cell checkpoints in autoimmune rheumatic diseases.
Rubin SJS, Bloom MS, Robinson WH. Rubin SJS, et al. Among authors: bloom ms. Nat Rev Rheumatol. 2019 May;15(5):303-315. doi: 10.1038/s41584-019-0211-0. Nat Rev Rheumatol. 2019. PMID: 30967621 Review.
B cells in rheumatoid arthritis synovial tissues encode focused antibody repertoires that include antibodies that stimulate macrophage TNF-α production.
Elliott SE, Kongpachith S, Lingampalli N, Adamska JZ, Cannon BJ, Blum LK, Bloom MS, Henkel M, McGeachy MJ, Moreland LW, Robinson WH. Elliott SE, et al. Among authors: bloom ms. Clin Immunol. 2020 Mar;212:108360. doi: 10.1016/j.clim.2020.108360. Epub 2020 Feb 5. Clin Immunol. 2020. PMID: 32035179 Free PMC article.
Neutralizing anti-IL-1 receptor antagonist autoantibodies induce inflammatory and fibrotic mediators in IgG4-related disease.
Jarrell JA, Baker MC, Perugino CA, Liu H, Bloom MS, Maehara T, Wong HH, Lanz TV, Adamska JZ, Kongpachith S, Sokolove J, Stone JH, Pillai SS, Robinson WH. Jarrell JA, et al. Among authors: bloom ms. J Allergy Clin Immunol. 2022 Jan;149(1):358-368. doi: 10.1016/j.jaci.2021.05.002. Epub 2021 May 8. J Allergy Clin Immunol. 2022. PMID: 33974929 Free PMC article.
Myeloablative autologous haematopoietic stem cell transplantation resets the B cell repertoire to a more naïve state in patients with systemic sclerosis.
Adamska JZ, Zia A, Bloom MS, Crofford LJ, Furst DE, Goldmuntz E, Keyes-Elstein L, Mayes MD, McSweeney P, Nash RA, Pinckney A, Welch B, Love ZZ, Sullivan KM, Robinson W. Adamska JZ, et al. Among authors: bloom ms. Ann Rheum Dis. 2023 Mar;82(3):357-364. doi: 10.1136/ard-2021-221925. Epub 2022 Oct 14. Ann Rheum Dis. 2023. PMID: 36241361 Free PMC article.
Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum.
Chriswell ME, Lefferts AR, Clay MR, Hsu AR, Seifert J, Feser ML, Rims C, Bloom MS, Bemis EA, Liu S, Maerz MD, Frank DN, Demoruelle MK, Deane KD, James EA, Buckner JH, Robinson WH, Holers VM, Kuhn KA. Chriswell ME, et al. Among authors: bloom ms. Sci Transl Med. 2022 Oct 26;14(668):eabn5166. doi: 10.1126/scitranslmed.abn5166. Epub 2022 Oct 26. Sci Transl Med. 2022. PMID: 36288282 Free PMC article.
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis.
Brewer RC, Lanz TV, Hale CR, Sepich-Poore GD, Martino C, Swafford AD, Carroll TS, Kongpachith S, Blum LK, Elliott SE, Blachere NE, Parveen S, Fak J, Yao V, Troyanskaya O, Frank MO, Bloom MS, Jahanbani S, Gomez AM, Iyer R, Ramadoss NS, Sharpe O, Chandrasekaran S, Kelmenson LB, Wang Q, Wong H, Torres HL, Wiesen M, Graves DT, Deane KD, Holers VM, Knight R, Darnell RB, Robinson WH, Orange DE. Brewer RC, et al. Among authors: bloom ms. Sci Transl Med. 2023 Feb 22;15(684):eabq8476. doi: 10.1126/scitranslmed.abq8476. Epub 2023 Feb 22. Sci Transl Med. 2023. PMID: 36812347 Free PMC article.
220 results