Wrobleski A - Search Results

1

Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor.

Durham TB, Hao J, Spinazze P, Stack DR, Toth JL, Massey S, Mbofana CT, Johnston RD, Lineswala JP, Wrobleski A, Mínguez JM, Perez C, Smith DL, Lamar J, Leon R, Corkins C, Durbin J, Tung F, Guo S, Linder RJ, Yumibe N, Wang W, MacKrell J, Antonellis M, Mascaro B. Durham TB, et al. Among authors: wrobleski a. J Med Chem. 2023 Dec 14;66(23):15960-15976. doi: 10.1021/acs.jmedchem.3c01410. Epub 2023 Nov 22. J Med Chem. 2023. PMID: 37992274

2

Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.

Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL. Henry JR, et al. Among authors: wrobleski ad. J Med Chem. 2015 May 28;58(10):4165-79. doi: 10.1021/acs.jmedchem.5b00067. Epub 2015 May 12. J Med Chem. 2015. PMID: 25965804

3

The Properties of Cysteine-Conjugated Antibody-Drug Conjugates Are Impacted by the IgG Subclass.

Datta-Mannan A, Choi H, Stokell D, Tang J, Murphy A, Wrobleski A, Feng Y. Datta-Mannan A, et al. Among authors: wrobleski a. AAPS J. 2018 Sep 25;20(6):103. doi: 10.1208/s12248-018-0263-0. AAPS J. 2018. PMID: 30255287

4

Total synthesis of the strychnos alkaloid (+)-minfiensine: tandem enantioselective intramolecular Heck-iminium ion cyclization.

Dounay AB, Humphreys PG, Overman LE, Wrobleski AD. Dounay AB, et al. Among authors: wrobleski ad. J Am Chem Soc. 2008 Apr 16;130(15):5368-77. doi: 10.1021/ja800163v. Epub 2008 Feb 28. J Am Chem Soc. 2008. PMID: 18303837 Free PMC article.

5

Sequential catalytic asymmetric Heck-iminium ion cyclization: enantioselective total synthesis of the Strychnos alkaloid minfiensine.

Dounay AB, Overman LE, Wrobleski AD. Dounay AB, et al. Among authors: wrobleski ad. J Am Chem Soc. 2005 Jul 27;127(29):10186-7. doi: 10.1021/ja0533895. J Am Chem Soc. 2005. PMID: 16028927

6

Regioselective single and double conjugate additions to substituted cyclohexa-2,5-dienone monoacetals.

Grecian S, Wrobleski AD, Aubé J. Grecian S, et al. Among authors: wrobleski ad. Org Lett. 2005 Jul 21;7(15):3167-70. doi: 10.1021/ol050715c. Org Lett. 2005. PMID: 16018612

7

Facile C-N cleavage in a series of bridged lactams.

Lei Y, Wrobleski AD, Golden JE, Powell DR, Aubé J. Lei Y, et al. Among authors: wrobleski ad. J Am Chem Soc. 2005 Apr 6;127(13):4552-3. doi: 10.1021/ja050214m. J Am Chem Soc. 2005. PMID: 15796502

8

Asymmetric total synthesis of dendrobatid alkaloids: preparation of indolizidine 251F and its 3-desmethyl analogue using an intramolecular Schmidt reaction strategy.

Wrobleski A, Sahasrabudhe K, Aubé J. Wrobleski A, et al. J Am Chem Soc. 2004 May 5;126(17):5475-81. doi: 10.1021/ja0320018. J Am Chem Soc. 2004. PMID: 15113219

9

Asymmetric total synthesis of dendrobatid alkaloid 251F.

Wrobleski A, Sahasrabudhe K, Aubé J. Wrobleski A, et al. J Am Chem Soc. 2002 Aug 28;124(34):9974-5. doi: 10.1021/ja027113y. J Am Chem Soc. 2002. PMID: 12188646

10

Double diastereoselective intramolecular cyclopropanation to P-chiral [3.1.0]-bicyclic phosphonates.

Moore JD, Sprott KT, Wrobleski AD, Hanson PR. Moore JD, et al. Among authors: wrobleski ad. Org Lett. 2002 Jul 11;4(14):2357-60. doi: 10.1021/ol026080o. Org Lett. 2002. PMID: 12098246

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