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Page 1
Identification of LY3522348: A Highly Selective and Orally Efficacious Ketohexokinase Inhibitor.
J Med Chem. 2023 Dec 14;66(23):15960-15976. doi: 10.1021/acs.jmedchem.3c01410. Epub 2023 Nov 22.
J Med Chem. 2023.
PMID: 37992274
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.
Hamdouchi C, Maiti P, Warshawsky AM, DeBaillie AC, Otto KA, Wilbur KL, Kahl SD, Patel Lewis A, Cardona GR, Zink RW, Chen K, Cr S, Lineswala JP, Neathery GL, Bouaichi C, Diseroad BA, Campbell AN, Sweetana SA, Adams LA, Cabrera O, Ma X, Yumibe NP, Montrose-Rafizadeh C, Chen Y, Miller AR.
Hamdouchi C, et al. Among authors: lineswala jp.
J Med Chem. 2018 Feb 8;61(3):934-945. doi: 10.1021/acs.jmedchem.7b01411. Epub 2018 Jan 5.
J Med Chem. 2018.
PMID: 29236497
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The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).
Hamdouchi C, Kahl SD, Patel Lewis A, Cardona GR, Zink RW, Chen K, Eessalu TE, Ficorilli JV, Marcelo MC, Otto KA, Wilbur KL, Lineswala JP, Piper JL, Coffey DS, Sweetana SA, Haas JV, Brooks DA, Pratt EJ, Belin RM, Deeg MA, Ma X, Cannady EA, Johnson JT, Yumibe NP, Chen Q, Maiti P, Montrose-Rafizadeh C, Chen Y, Reifel Miller A.
Hamdouchi C, et al. Among authors: lineswala jp.
J Med Chem. 2016 Dec 22;59(24):10891-10916. doi: 10.1021/acs.jmedchem.6b00892. Epub 2016 Nov 11.
J Med Chem. 2016.
PMID: 27749056
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Novel lavendamycin analogues as antitumor agents: synthesis, in vitro cytotoxicity, structure-metabolism, and computational molecular modeling studies with NAD(P)H:quinone oxidoreductase 1.
Hassani M, Cai W, Holley DC, Lineswala JP, Maharjan BR, Ebrahimian GR, Seradj H, Stocksdale MG, Mohammadi F, Marvin CC, Gerdes JM, Beall HD, Behforouz M.
Hassani M, et al. Among authors: lineswala jp.
J Med Chem. 2005 Dec 1;48(24):7733-49. doi: 10.1021/jm050758z.
J Med Chem. 2005.
PMID: 16302813
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Synthesis, metabolism and in vitro cytotoxicity studies on novel lavendamycin antitumor agents.
Cai W, Hassani M, Karki R, Walter ED, Koelsch KH, Seradj H, Lineswala JP, Mirzaei H, York JS, Olang F, Sedighi M, Lucas JS, Eads TJ, Rose AS, Charkhzarrin S, Hermann NG, Beall HD, Behforouz M.
Cai W, et al. Among authors: lineswala jp.
Bioorg Med Chem. 2010 Mar 1;18(5):1899-909. doi: 10.1016/j.bmc.2010.01.037. Epub 2010 Jan 25.
Bioorg Med Chem. 2010.
PMID: 20149966
Free PMC article.
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Lavendamycin antitumor agents: structure-based design, synthesis, and NAD(P)H:quinone oxidoreductase 1 (NQO1) model validation with molecular docking and biological studies.
Hassani M, Cai W, Koelsch KH, Holley DC, Rose AS, Olang F, Lineswala JP, Holloway WG, Gerdes JM, Behforouz M, Beall HD.
Hassani M, et al. Among authors: lineswala jp.
J Med Chem. 2008 Jun 12;51(11):3104-15. doi: 10.1021/jm701066a. Epub 2008 May 6.
J Med Chem. 2008.
PMID: 18457384
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Structural basis for GPR40 allosteric agonism and incretin stimulation.
Ho JD, Chau B, Rodgers L, Lu F, Wilbur KL, Otto KA, Chen Y, Song M, Riley JP, Yang HC, Reynolds NA, Kahl SD, Lewis AP, Groshong C, Madsen RE, Conners K, Lineswala JP, Gheyi T, Saflor MD, Lee MR, Benach J, Baker KA, Montrose-Rafizadeh C, Genin MJ, Miller AR, Hamdouchi C.
Ho JD, et al. Among authors: lineswala jp.
Nat Commun. 2018 Apr 25;9(1):1645. doi: 10.1038/s41467-017-01240-w.
Nat Commun. 2018.
PMID: 29695780
Free PMC article.
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Indolocarbazole poisons of human topoisomerase I: regioisomeric analogues of ED-110.
Zembower DE, Zhang H, Lineswala JP, Kuffel MJ, Aytes SA, Ames MM.
Zembower DE, et al. Among authors: lineswala jp.
Bioorg Med Chem Lett. 1999 Jan 18;9(2):145-50. doi: 10.1016/s0960-894x(98)00710-0.
Bioorg Med Chem Lett. 1999.
PMID: 10021917
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