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Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitors.
Marzaro G, Coluccia A, Ferrarese A, Brun P, Castagliuolo I, Conconi MT, La Regina G, Bai R, Silvestri R, Hamel E, Chilin A. Marzaro G, et al. Among authors: bai r. J Med Chem. 2014 Jun 12;57(11):4598-4605. doi: 10.1021/jm500034j. Epub 2014 May 14. J Med Chem. 2014. PMID: 24801610 Free PMC article.
Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors.
Spanò V, Barreca M, Rocca R, Bortolozzi R, Bai R, Carbone A, Raimondi MV, Piccionello AP, Montalbano A, Alcaro S, Hamel E, Viola G, Barraja P. Spanò V, et al. Among authors: bai r. Eur J Med Chem. 2021 Feb 15;212:113122. doi: 10.1016/j.ejmech.2020.113122. Epub 2020 Dec 24. Eur J Med Chem. 2021. PMID: 33401199
Discovery and preclinical evaluation of 7-benzyl-N-(substituted)-pyrrolo[3,2-d]pyrimidin-4-amines as single agents with microtubule targeting effects along with triple-acting angiokinase inhibition as antitumor agents.
Pavana RK, Choudhary S, Bastian A, Ihnat MA, Bai R, Hamel E, Gangjee A. Pavana RK, et al. Among authors: bai r. Bioorg Med Chem. 2017 Jan 15;25(2):545-556. doi: 10.1016/j.bmc.2016.11.026. Epub 2016 Nov 15. Bioorg Med Chem. 2017. PMID: 27894589 Free PMC article.
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors.
La Regina G, Bai R, Coluccia A, Naccarato V, Famiglini V, Nalli M, Masci D, Verrico A, Rovella P, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Vultaggio S, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R. La Regina G, et al. Among authors: bai r. Eur J Med Chem. 2018 May 25;152:283-297. doi: 10.1016/j.ejmech.2018.04.042. Epub 2018 Apr 25. Eur J Med Chem. 2018. PMID: 29730191
Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.
Morigi R, Locatelli A, Leoni A, Rambaldi M, Bortolozzi R, Mattiuzzo E, Ronca R, Maccarinelli F, Hamel E, Bai R, Brancale A, Viola G. Morigi R, et al. Among authors: bai r. Eur J Med Chem. 2019 Mar 15;166:514-530. doi: 10.1016/j.ejmech.2019.01.049. Epub 2019 Jan 26. Eur J Med Chem. 2019. PMID: 30784885
2,215 results