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Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O6-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O6-Alkylguanine Adductome.
Abdelhady R, Senthong P, Eyers CE, Reamtong O, Cowley E, Cannizzaro L, Stimpson J, Cain K, Wilkinson OJ, Williams NH, Barran PE, Margison GP, Williams DM, Povey AC. Abdelhady R, et al. Among authors: povey ac. Chem Res Toxicol. 2023 Dec 18;36(12):1921-1929. doi: 10.1021/acs.chemrestox.3c00207. Epub 2023 Nov 20. Chem Res Toxicol. 2023. PMID: 37983188 Free PMC article.
The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase.
Senthong P, Millington CL, Wilkinson OJ, Marriott AS, Watson AJ, Reamtong O, Eyers CE, Williams DM, Margison GP, Povey AC. Senthong P, et al. Among authors: povey ac. Nucleic Acids Res. 2013 Mar 1;41(5):3047-55. doi: 10.1093/nar/gks1476. Epub 2013 Jan 17. Nucleic Acids Res. 2013. PMID: 23335782 Free PMC article.
Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O6-methylguanine and their recognition by MGMT and Atl1.
Abdu K, Aiertza MK, Wilkinson OJ, Senthong P, Craggs TD, Povey AC, Margison GP, Williams DM. Abdu K, et al. Among authors: povey ac. Nucleosides Nucleotides Nucleic Acids. 2020;39(8):1108-1121. doi: 10.1080/15257770.2020.1764971. Epub 2020 May 23. Nucleosides Nucleotides Nucleic Acids. 2020. PMID: 32449465 Free article.
119 results