Margison GP - Search Results

1

Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O⁶-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O⁶-Alkylguanine Adductome.

Abdelhady R, Senthong P, Eyers CE, Reamtong O, Cowley E, Cannizzaro L, Stimpson J, Cain K, Wilkinson OJ, Williams NH, Barran PE, Margison GP, Williams DM, Povey AC. Abdelhady R, et al. Among authors: margison gp. Chem Res Toxicol. 2023 Dec 18;36(12):1921-1929. doi: 10.1021/acs.chemrestox.3c00207. Epub 2023 Nov 20. Chem Res Toxicol. 2023. PMID: 37983188 Free PMC article.

2

The DNA Alkyltransferase Family of DNA Repair Proteins: Common Mechanisms, Diverse Functions.

Tessmer I, Margison GP. Tessmer I, et al. Among authors: margison gp. Int J Mol Sci. 2023 Dec 29;25(1):463. doi: 10.3390/ijms25010463. Int J Mol Sci. 2023. PMID: 38203633 Free PMC article. Review.

3

QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency.

Sun G, Bai P, Fan T, Zhao L, Zhong R, McElhinney RS, McMurry TBH, Donnelly DJ, McCormick JE, Kelly J, Margison GP. Sun G, et al. Among authors: margison gp. Pharmaceutics. 2023 Aug 21;15(8):2170. doi: 10.3390/pharmaceutics15082170. Pharmaceutics. 2023. PMID: 37631385 Free PMC article.

4

Synthesis of oligodeoxyribonucleotides containing a tricyclic thio analogue of O⁶-methylguanine and their recognition by MGMT and Atl1.

Abdu K, Aiertza MK, Wilkinson OJ, Senthong P, Craggs TD, Povey AC, Margison GP, Williams DM. Abdu K, et al. Among authors: margison gp. Nucleosides Nucleotides Nucleic Acids. 2020;39(8):1108-1121. doi: 10.1080/15257770.2020.1764971. Epub 2020 May 23. Nucleosides Nucleotides Nucleic Acids. 2020. PMID: 32449465 Free article.

5

PON1 increases cellular DNA damage by lactone substrates.

Shangula S, Noori M, Ahmad I, Margison GP, Liu Y, Siahmansur T, Soran H, Povey AC. Shangula S, et al. Among authors: margison gp. Arch Toxicol. 2019 Jul;93(7):2035-2043. doi: 10.1007/s00204-019-02475-w. Epub 2019 Jun 17. Arch Toxicol. 2019. PMID: 31209508

6

O⁶-methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function.

Ezerskyte M, Paredes JA, Malvezzi S, Burns JA, Margison GP, Olsson M, Scicchitano DA, Dreij K. Ezerskyte M, et al. Among authors: margison gp. Proc Natl Acad Sci U S A. 2018 May 1;115(18):4731-4736. doi: 10.1073/pnas.1721764115. Epub 2018 Apr 17. Proc Natl Acad Sci U S A. 2018. PMID: 29666243 Free PMC article.

7

L-β-N-methylamino-l-alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease.

Potjewyd G, Day PJ, Shangula S, Margison GP, Povey AC. Potjewyd G, et al. Among authors: margison gp. Neurotoxicology. 2017 Mar;59:105-109. doi: 10.1016/j.neuro.2017.01.007. Epub 2017 Feb 3. Neurotoxicology. 2017. PMID: 28163087

8

IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide.

Ramcharan R, Aleksic T, Kamdoum WP, Gao S, Pfister SX, Tanner J, Bridges E, Asher R, Watson AJ, Margison GP, Woodcock M, Repapi E, Li JL, Middleton MR, Macaulay VM. Ramcharan R, et al. Among authors: margison gp. Oncotarget. 2015 Nov 24;6(37):39877-90. doi: 10.18632/oncotarget.5631. Oncotarget. 2015. PMID: 26497996 Free PMC article.

9

MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide.

Erice O, Smith MP, White R, Goicoechea I, Barriuso J, Jones C, Margison GP, Acosta JC, Wellbrock C, Arozarena I. Erice O, et al. Among authors: margison gp. Mol Cancer Ther. 2015 May;14(5):1236-46. doi: 10.1158/1535-7163.MCT-14-0810. Epub 2015 Mar 16. Mol Cancer Ther. 2015. PMID: 25777962

10

The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity.

Tomaszowski KH, Aasland D, Margison GP, Williams E, Pinder SI, Modesti M, Fuchs RP, Kaina B. Tomaszowski KH, et al. Among authors: margison gp. DNA Repair (Amst). 2015 Apr;28:14-20. doi: 10.1016/j.dnarep.2015.01.009. Epub 2015 Jan 31. DNA Repair (Amst). 2015. PMID: 25703834

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