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Cardioprotection by the adiponectin receptor agonist ALY688 in a preclinical mouse model of heart failure with reduced ejection fraction (HFrEF).
Cho S, Dadson K, Sung HK, Ayansola O, Mirzaesmaeili A, Noskovicova N, Zhao Y, Cheung K, Radisic M, Hinz B, Sater AAA, Hsu HH, Lopaschuk GD, Sweeney G. Cho S, et al. Among authors: lopaschuk gd. Biomed Pharmacother. 2024 Feb;171:116119. doi: 10.1016/j.biopha.2023.116119. Epub 2024 Jan 4. Biomed Pharmacother. 2024. PMID: 38181714 Free article.
Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis.
Gopal K, Abdualkader AM, Li X, Greenwell AA, Karwi QG, Altamimi TR, Saed C, Uddin GM, Darwesh AM, Jamieson KL, Kim R, Eaton F, Seubert JM, Lopaschuk GD, Ussher JR, Al Batran R. Gopal K, et al. Among authors: lopaschuk gd. J Biol Chem. 2023 Dec;299(12):105375. doi: 10.1016/j.jbc.2023.105375. Epub 2023 Oct 20. J Biol Chem. 2023. PMID: 37865313 Free PMC article.
Erratum: Author correction to 'Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy' [Acta Pharmaceutica Sinica B 11 (2021) 3508-3526].
Wang S, Tao J, Chen H, Kandadi MR, Sun M, Xu H, Lopaschuk GD, Lu Y, Zheng J, Peng H, Ren J. Wang S, et al. Among authors: lopaschuk gd. Acta Pharm Sin B. 2023 Feb;13(2):897-898. doi: 10.1016/j.apsb.2022.12.015. Epub 2022 Dec 22. Acta Pharm Sin B. 2023. PMID: 36873171 Free PMC article.
Iron drives anabolic metabolism through active histone demethylation and mTORC1.
Shapiro JS, Chang HC, Tatekoshi Y, Zhao Z, Waxali ZS, Hong BJ, Chen H, Geier JA, Bartom ET, De Jesus A, Nejad FK, Mahmoodzadeh A, Sato T, Ramos-Alonso L, Romero AM, Martinez-Pastor MT, Jiang SC, Sah-Teli SK, Li L, Bentrem D, Lopaschuk G, Ben-Sahra I, O'Halloran TV, Shilatifard A, Puig S, Bergelson J, Koivunen P, Ardehali H. Shapiro JS, et al. Nat Cell Biol. 2023 Oct;25(10):1478-1494. doi: 10.1038/s41556-023-01225-6. Epub 2023 Sep 25. Nat Cell Biol. 2023. PMID: 37749225
Impaired Cardiac AMPK (5'-Adenosine Monophosphate-Activated Protein Kinase) and Ca2+-Handling, and Action Potential Duration Heterogeneity in Ibrutinib-Induced Ventricular Arrhythmia Vulnerability.
Zhao Y, Du B, Chakraborty P, Denham N, Massé S, Lai PFH, Azam MA, Billia F, Thavendiranathan P, Abdel-Qadir H, Lopaschuk GD, Nanthakumar K. Zhao Y, et al. Among authors: lopaschuk gd. J Am Heart Assoc. 2024 Jun 6:e032357. doi: 10.1161/JAHA.123.032357. Online ahead of print. J Am Heart Assoc. 2024. PMID: 38842296 Free article.
415 results