Jones LH - Search Results

1

Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange.

Cruite JT, Nowak RP, Donovan KA, Ficarro SB, Huang H, Liu H, Liu Y, Marto JA, Metivier RJ, Fischer ES, Jones LH. Cruite JT, et al. Among authors: jones lh. ACS Med Chem Lett. 2023 Oct 24;14(11):1576-1581. doi: 10.1021/acsmedchemlett.3c00371. eCollection 2023 Nov 9. ACS Med Chem Lett. 2023. PMID: 37974938

2

Target Validation Using PROTACs: Applying the Four Pillars Framework.

Nowak RP, Jones LH. Nowak RP, et al. Among authors: jones lh. SLAS Discov. 2021 Apr;26(4):474-483. doi: 10.1177/2472555220979584. Epub 2020 Dec 17. SLAS Discov. 2021. PMID: 33334221 Free article. Review.

3

Structure-based design and analysis of SuFEx chemical probes.

Jones LH, Kelly JW. Jones LH, et al. RSC Med Chem. 2020 Jan 6;11(1):10-17. doi: 10.1039/c9md00542k. eCollection 2020 Jan 1. RSC Med Chem. 2020. PMID: 33479601 Free PMC article. Review.

4

Physicochemistry of Cereblon Modulating Drugs Determines Pharmacokinetics and Disposition.

Kong NR, Liu H, Che J, Jones LH. Kong NR, et al. Among authors: jones lh. ACS Med Chem Lett. 2021 Oct 8;12(11):1861-1865. doi: 10.1021/acsmedchemlett.1c00475. eCollection 2021 Nov 11. ACS Med Chem Lett. 2021. PMID: 34795877 Free PMC article.

5

Small molecule modulation of protein polymerization.

Fischer ES, Jones LH. Fischer ES, et al. Among authors: jones lh. Chem Soc Rev. 2022 Apr 4;51(7):2392-2396. doi: 10.1039/d2cs00070a. Chem Soc Rev. 2022. PMID: 35266488 Review.

6

Cereblon covalent modulation through structure-based design of histidine targeting chemical probes.

Cruite JT, Dann GP, Che J, Donovan KA, Ferrao S, Ficarro SB, Fischer ES, Gray NS, Huerta F, Kong NR, Liu H, Marto JA, Metivier RJ, Nowak RP, Zerfas BL, Jones LH. Cruite JT, et al. Among authors: jones lh. RSC Chem Biol. 2022 Jul 8;3(9):1105-1110. doi: 10.1039/d2cb00078d. eCollection 2022 Aug 31. RSC Chem Biol. 2022. PMID: 36128501 Free PMC article.

7

Covalent drugs targeting histidine - an unexploited opportunity?

Che J, Jones LH. Che J, et al. Among authors: jones lh. RSC Med Chem. 2022 Sep 28;13(10):1121-1126. doi: 10.1039/d2md00258b. eCollection 2022 Oct 19. RSC Med Chem. 2022. PMID: 36325394 Free PMC article.

8

Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives.

Nowak RP, Che J, Ferrao S, Kong NR, Liu H, Zerfas BL, Jones LH. Nowak RP, et al. Among authors: jones lh. RSC Med Chem. 2023 Jan 26;14(3):501-506. doi: 10.1039/d2md00347c. eCollection 2023 Mar 22. RSC Med Chem. 2023. PMID: 36970148 Free PMC article.

9

HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development.

Tsang T, Huerta F, Liu Y, Che J, Metivier RJ, Ferrao S, Donovan KA, Jones LH, Zerfas BL, Nowak RP. Tsang T, et al. Among authors: jones lh. ACS Chem Biol. 2023 Apr 21;18(4):933-941. doi: 10.1021/acschembio.3c00084. Epub 2023 Apr 5. ACS Chem Biol. 2023. PMID: 37018062

10

Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions.

Gao Y, Jiang B, Kim H, Berberich MJ, Che J, Donovan KA, Hatcher JM, Huerta F, Kwiatkowski NP, Liu Y, Liuni PP, Metivier RJ, Murali VK, Nowak RP, Zhang T, Fischer ES, Gray NS, Jones LH. Gao Y, et al. Among authors: jones lh. J Med Chem. 2023 Apr 27;66(8):5524-5535. doi: 10.1021/acs.jmedchem.2c01864. Epub 2023 Apr 10. J Med Chem. 2023. PMID: 37036171

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