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A model-based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno-oncology.
Sánchez J, Claus C, Albrecht R, Gaillard BC, Marinho J, McIntyre C, Tanos T, Boehnke A, Friberg LE, Jönsson S, Frances N. Sánchez J, et al. Among authors: tanos t. CPT Pharmacometrics Syst Pharmacol. 2023 Nov;12(11):1804-1818. doi: 10.1002/psp4.13065. Epub 2023 Nov 15. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37964753 Free PMC article.
A first-in-human study of the fibroblast activation protein-targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors.
Melero I, Tanos T, Bustamante M, Sanmamed MF, Calvo E, Moreno I, Moreno V, Hernandez T, Martinez Garcia M, Rodriguez-Vida A, Tabernero J, Azaro A, Ponz-Sarvisé M, Spanggaard I, Rohrberg K, Guarin E, Nüesch E, Davydov II, Ooi C, Duarte J, Chesne E, McIntyre C, Ceppi M, Cañamero M, Krieter O. Melero I, et al. Among authors: tanos t. Sci Transl Med. 2023 May 10;15(695):eabp9229. doi: 10.1126/scitranslmed.abp9229. Epub 2023 May 10. Sci Transl Med. 2023. PMID: 37163618
Progesterone/RANKL is a major regulatory axis in the human breast.
Tanos T, Sflomos G, Echeverria PC, Ayyanan A, Gutierrez M, Delaloye JF, Raffoul W, Fiche M, Dougall W, Schneider P, Yalcin-Ozuysal O, Brisken C. Tanos T, et al. Sci Transl Med. 2013 Apr 24;5(182):182ra55. doi: 10.1126/scitranslmed.3005654. Sci Transl Med. 2013. PMID: 23616122 Free article.
The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis.
Martín MJ, Tanos T, García AB, Martin D, Gutkind JS, Coso OA, Marinissen MJ. Martín MJ, et al. Among authors: tanos t. J Biol Chem. 2007 Nov 23;282(47):34510-24. doi: 10.1074/jbc.M703043200. Epub 2007 Sep 19. J Biol Chem. 2007. PMID: 17881360 Free article.
21 results