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Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
Moreira DR, Costa SP, Hernandes MZ, Rabello MM, de Oliveira Filho GB, de Melo CM, da Rocha LF, de Simone CA, Ferreira RS, Fradico JR, Meira CS, Guimarães ET, Srivastava RM, Pereira VR, Soares MB, Leite AC. Moreira DR, et al. Among authors: meira cs. J Med Chem. 2012 Dec 27;55(24):10918-36. doi: 10.1021/jm301518v. Epub 2012 Dec 7. J Med Chem. 2012. PMID: 23167554
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathy.
Vasconcelos JF, Souza BS, Lins TF, Garcia LM, Kaneto CM, Sampaio GP, de Alcântara AC, Meira CS, Macambira SG, Ribeiro-dos-Santos R, Soares MB. Vasconcelos JF, et al. Among authors: meira cs. FASEB J. 2013 Dec;27(12):4691-702. doi: 10.1096/fj.13-229351. Epub 2013 Aug 20. FASEB J. 2013. PMID: 23964077
Nitro/nitrosyl-ruthenium complexes are potent and selective anti-Trypanosoma cruzi agents causing autophagy and necrotic parasite death.
Bastos TM, Barbosa MI, da Silva MM, da C Júnior JW, Meira CS, Guimaraes ET, Ellena J, Moreira DR, Batista AA, Soares MB. Bastos TM, et al. Among authors: meira cs. Antimicrob Agents Chemother. 2014 Oct;58(10):6044-55. doi: 10.1128/AAC.02765-14. Epub 2014 Aug 4. Antimicrob Agents Chemother. 2014. PMID: 25092707 Free PMC article.
Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: Cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole.
Corrêa RS, da Silva MM, Graminha AE, Meira CS, Santos JA, Moreira DR, Soares MB, Von Poelhsitz G, Castellano EE, Bloch C Jr, Cominetti MR, Batista AA. Corrêa RS, et al. Among authors: meira cs. J Inorg Biochem. 2016 Mar;156:153-63. doi: 10.1016/j.jinorgbio.2015.12.024. Epub 2016 Jan 2. J Inorg Biochem. 2016. PMID: 26795676
Physalin F, a seco-steroid from Physalis angulata L., has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy.
Pinto LA, Meira CS, Villarreal CF, Vannier-Santos MA, de Souza CV, Ribeiro IM, Tomassini TC, Galvão-Castro B, Soares MB, Grassi MF. Pinto LA, et al. Among authors: meira cs. Biomed Pharmacother. 2016 Apr;79:129-34. doi: 10.1016/j.biopha.2016.01.041. Epub 2016 Feb 19. Biomed Pharmacother. 2016. PMID: 27044821 Free article.
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