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N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils.
Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A. Bergfeld AK, et al. Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8155-E8164. doi: 10.1073/pnas.1706306114. Epub 2017 Sep 11. Proc Natl Acad Sci U S A. 2017. PMID: 28893995 Free PMC article.
A red meat-derived glycan promotes inflammation and cancer progression.
Samraj AN, Pearce OM, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A. Samraj AN, et al. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):542-7. doi: 10.1073/pnas.1417508112. Epub 2014 Dec 29. Proc Natl Acad Sci U S A. 2015. PMID: 25548184 Free PMC article.
Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine.
Bergfeld AK, Pearce OM, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD, Varki A. Bergfeld AK, et al. J Biol Chem. 2012 Aug 17;287(34):28898-916. doi: 10.1074/jbc.M112.363499. Epub 2012 Jun 12. J Biol Chem. 2012. PMID: 22692203 Free PMC article.
To date, hydroxylation of CMP-Neu5Ac resulting in the conversion into CMP-Neu5Gc is the only known enzymatic reaction in mammals to synthesize a monosaccharide carrying an N-glycolyl group. In our accompanying paper (Bergfeld, A. K., Pearce, O. M., Diaz, S. L., Pham …
To date, hydroxylation of CMP-Neu5Ac resulting in the conversion into CMP-Neu5Gc is the only known enzymatic reaction in mammals to synthesi …
Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment.
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joy JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P, Balkwill FR. Maniati E, et al. Among authors: pearce omt. Cell Rep. 2020 Jan 14;30(2):525-540.e7. doi: 10.1016/j.celrep.2019.12.034. Cell Rep. 2020. PMID: 31940494 Free PMC article.
Enhanced T cell function in a mouse model of human glycosylation.
Buchlis G, Odorizzi P, Soto PC, Pearce OM, Hui DJ, Jordan MS, Varki A, Wherry EJ, High KA. Buchlis G, et al. J Immunol. 2013 Jul 1;191(1):228-37. doi: 10.4049/jimmunol.1202905. Epub 2013 May 24. J Immunol. 2013. PMID: 23709682 Free PMC article.
103 results