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The inhibition of inner mitochondrial fusion in hepatocytes reduces non-alcoholic fatty liver and improves metabolic profile during obesity by modulating bile acid conjugation.
Da Dalt L, Moregola A, Svecla M, Pedretti S, Fantini F, Ronzio M, Uboldi P, Dolfini D, Donetti E, Baragetti A, Mitro N, Scorrano L, Norata GD. Da Dalt L, et al. Among authors: mitro n. Cardiovasc Res. 2024 Feb 17;119(18):2917-2929. doi: 10.1093/cvr/cvad169. Cardiovasc Res. 2024. PMID: 37922889
N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.
Molteni V, Li X, Nabakka J, Liang F, Wityak J, Koder A, Vargas L, Romeo R, Mitro N, Mak PA, Seidel HM, Haslam JA, Chow D, Tuntland T, Spalding TA, Brock A, Bradley M, Castrillo A, Tontonoz P, Saez E. Molteni V, et al. Among authors: mitro n. J Med Chem. 2007 Aug 23;50(17):4255-9. doi: 10.1021/jm070453f. Epub 2007 Aug 1. J Med Chem. 2007. PMID: 17665897
Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis.
Pochetti G, Mitro N, Lavecchia A, Gilardi F, Besker N, Scotti E, Aschi M, Re N, Fracchiolla G, Laghezza A, Tortorella P, Montanari R, Novellino E, Mazza F, Crestani M, Loiodice F. Pochetti G, et al. Among authors: mitro n. J Med Chem. 2010 Jun 10;53(11):4354-66. doi: 10.1021/jm9013899. J Med Chem. 2010. PMID: 20462215
Age-related changes in bile acid synthesis and hepatic nuclear receptor expression.
Bertolotti M, Gabbi C, Anzivino C, Crestani M, Mitro N, Del Puppo M, Godio C, De Fabiani E, Macchioni D, Carulli L, Rossi A, Ricchi M, Loria P, Carulli N. Bertolotti M, et al. Among authors: mitro n. Eur J Clin Invest. 2007 Jun;37(6):501-8. doi: 10.1111/j.1365-2362.2007.01808.x. Eur J Clin Invest. 2007. PMID: 17537158 Free article.
The nuclear receptor LXR is a glucose sensor.
Mitro N, Mak PA, Vargas L, Godio C, Hampton E, Molteni V, Kreusch A, Saez E. Mitro N, et al. Nature. 2007 Jan 11;445(7124):219-23. doi: 10.1038/nature05449. Epub 2006 Dec 24. Nature. 2007. PMID: 17187055
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
Pochetti G, Godio C, Mitro N, Caruso D, Galmozzi A, Scurati S, Loiodice F, Fracchiolla G, Tortorella P, Laghezza A, Lavecchia A, Novellino E, Mazza F, Crestani M. Pochetti G, et al. Among authors: mitro n. J Biol Chem. 2007 Jun 8;282(23):17314-24. doi: 10.1074/jbc.M702316200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403688 Free article.
145 results