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In vitro evaluation of 2-(1H-pyrazol-1-yl)-1,3,4-thiadiazole derivatives against replicative and infective stages of Trypanosoma cruzi.
Faria AFM, de Souza Ferreira Pereira C, Teixeira GP, Dos Santos Galvão RM, Pacheco PAF, Bello ML, de Jesus DH, Calabrese K, Gonzaga DTG, Boechat N, Faria RX. Faria AFM, et al. Among authors: pacheco paf. J Bioenerg Biomembr. 2023 Dec;55(6):409-421. doi: 10.1007/s10863-023-09982-7. Epub 2023 Nov 3. J Bioenerg Biomembr. 2023. PMID: 37919636
Triazoles with inhibitory action on P2X7R impaired the acute inflammatory response in vivo and modulated the hemostatic balance in vitro and ex vivo.
Pinheiro NG, Gonzaga DTG, da Silva AR, Fuly AL, von Ranke NL, Rodrigues CR, Magalhães BQ, Pereira JS, Pacheco PAF, Silva AC, Ferreira VF, de Carvalho da Silva F, Faria RX. Pinheiro NG, et al. Among authors: pacheco paf. Inflamm Res. 2023 Feb;72(2):237-250. doi: 10.1007/s00011-022-01664-1. Epub 2022 Dec 3. Inflamm Res. 2023. PMID: 36463339 Free PMC article.
Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds.
Guilhon-Simplicio F, Serrão CKR, Pinto ACDS, Pacheco PAF, Faria RX, da Rocha DR, Ferreira VF, Pereira-Junior RC, Matheeussen A, Baán A, Kiekens F, de Meneses Pereira M, Lima ES, Winter H, Cos P. Guilhon-Simplicio F, et al. Among authors: pacheco paf. Chem Biol Drug Des. 2022 Jun;99(6):868-883. doi: 10.1111/cbdd.14040. Epub 2022 Mar 31. Chem Biol Drug Des. 2022. PMID: 35313075
20 results