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Improving Intracellular Delivery of an Antibody-Drug Conjugate Targeting Carcinoembryonic Antigen Increases Efficacy at Clinically Relevant Doses In Vivo.
Mol Cancer Ther. 2024 Mar 4;23(3):343-353. doi: 10.1158/1535-7163.MCT-23-0437.
Mol Cancer Ther. 2024.
PMID: 37913500
Antibody-Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release.
Kopp A, Hofsess S, Cardillo TM, Govindan SV, Donnell J, Thurber GM.
Kopp A, et al. Among authors: hofsess s.
Mol Cancer Ther. 2023 Jan 3;22(1):102-111. doi: 10.1158/1535-7163.MCT-22-0375.
Mol Cancer Ther. 2023.
PMID: 36190986
Free PMC article.
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Final Results From the Randomized Phase III ASCENT Clinical Trial in Metastatic Triple-Negative Breast Cancer and Association of Outcomes by Human Epidermal Growth Factor Receptor 2 and Trophoblast Cell Surface Antigen 2 Expression.
Bardia A, Rugo HS, Tolaney SM, Loirat D, Punie K, Oliveira M, Brufsky A, Kalinsky K, Cortés J, Shaughnessy JO, Diéras V, Carey LA, Gianni L, Piccart-Gebhart M, Loibl S, Yoon OK, Pan Y, Hofsess S, Phan SC, Hurvitz SA.
Bardia A, et al. Among authors: hofsess s.
J Clin Oncol. 2024 May 20;42(15):1738-1744. doi: 10.1200/JCO.23.01409. Epub 2024 Feb 29.
J Clin Oncol. 2024.
PMID: 38422473
Free PMC article.
Clinical Trial.
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Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.
Edmondson SD, Mastracchio A, He J, Chung CC, Forrest MJ, Hofsess S, MacIntyre E, Metzger J, O'Connor N, Patel K, Tong X, Tota MR, Van der Ploeg LH, Varnerin JP, Fisher MH, Wyvratt MJ, Weber AE, Parmee ER.
Edmondson SD, et al. Among authors: hofsess s.
Bioorg Med Chem Lett. 2003 Nov 17;13(22):3983-7. doi: 10.1016/j.bmcl.2003.08.056.
Bioorg Med Chem Lett. 2003.
PMID: 14592490
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Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
Liverton NJ, Butcher JW, Claiborne CF, Claremon DA, Libby BE, Nguyen KT, Pitzenberger SM, Selnick HG, Smith GR, Tebben A, Vacca JP, Varga SL, Agarwal L, Dancheck K, Forsyth AJ, Fletcher DS, Frantz B, Hanlon WA, Harper CF, Hofsess SJ, Kostura M, Lin J, Luell S, O'Neill EA, O'Keefe SJ, et al.
Liverton NJ, et al. Among authors: hofsess sj.
J Med Chem. 1999 Jun 17;42(12):2180-90. doi: 10.1021/jm9805236.
J Med Chem. 1999.
PMID: 10377223
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