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Treatment with the dual-incretin agonist DA-CH5 demonstrates potent therapeutic effect in a rat model of Wolfram Syndrome.
Front Endocrinol (Lausanne). 2023 Oct 13;14:1234925. doi: 10.3389/fendo.2023.1234925. eCollection 2023.
Front Endocrinol (Lausanne). 2023.
PMID: 37900147
Free PMC article.
Liraglutide, 7,8-DHF and their co-treatment prevents loss of vision and cognitive decline in a Wolfram syndrome rat model.
Seppa K, Jagomäe T, Kukker KG, Reimets R, Pastak M, Vasar E, Terasmaa A, Plaas M.
Seppa K, et al. Among authors: pastak m.
Sci Rep. 2021 Jan 26;11(1):2275. doi: 10.1038/s41598-021-81768-6.
Sci Rep. 2021.
PMID: 33500541
Free PMC article.
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Early Intervention and Lifelong Treatment with GLP1 Receptor Agonist Liraglutide in a Wolfram Syndrome Rat Model with an Emphasis on Visual Neurodegeneration, Sensorineural Hearing Loss and Diabetic Phenotype.
Jagomäe T, Seppa K, Reimets R, Pastak M, Plaas M, Hickey MA, Kukker KG, Moons L, De Groef L, Vasar E, Kaasik A, Terasmaa A, Plaas M.
Jagomäe T, et al. Among authors: pastak m.
Cells. 2021 Nov 16;10(11):3193. doi: 10.3390/cells10113193.
Cells. 2021.
PMID: 34831417
Free PMC article.
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Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal Transplantation.
Pastak M, Kleff V, Saban DR, Czugala M, Steuhl KP, Ergün S, Singer BB, Fuchsluger TA.
Pastak M, et al.
Hum Gene Ther. 2018 Apr;29(4):467-479. doi: 10.1089/hum.2017.044. Epub 2017 Oct 6.
Hum Gene Ther. 2018.
PMID: 28990426
Free PMC article.
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Dietary sugar and salt represent real risk factors for cataract development.
Veromann S, Sünter A, Tasa G, Juronen E, Panov A, Pastak M, Kaljurand K.
Veromann S, et al. Among authors: pastak m.
Ophthalmologica. 2003 Jul-Aug;217(4):302-7. doi: 10.1159/000070640.
Ophthalmologica. 2003.
PMID: 12792139
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Adjunctive use of tafluprost with timolol provides additive effects for reduction of intraocular pressure in patients with glaucoma.
Egorov E, Ropo A; Investigators.
Egorov E, et al.
Eur J Ophthalmol. 2009 Mar-Apr;19(2):214-22. doi: 10.1177/112067210901900207.
Eur J Ophthalmol. 2009.
PMID: 19253237
Clinical Trial.
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