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Page 1
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice.
Green CL, Trautman ME, Chaiyakul K, Jain R, Alam YH, Babygirija R, Pak HH, Sonsalla MM, Calubag MF, Yeh CY, Bleicher A, Novak G, Liu TT, Newman S, Ricke WA, Matkowskyj KA, Ong IM, Jang C, Simcox J, Lamming DW. Green CL, et al. Among authors: simcox j. Cell Metab. 2023 Nov 7;35(11):1976-1995.e6. doi: 10.1016/j.cmet.2023.10.005. Cell Metab. 2023. PMID: 37939658
Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
Varadharajan V, Ramachandiran I, Massey WJ, Jain R, Banerjee R, Horak AJ, McMullen MR, Huang E, Bellar A, Lorkowski SW, Gulshan K, Helsley RN, James I, Pathak V, Dasarathy J, Welch N, Dasarathy S, Streem D, Reizes O, Allende DS, Smith JD, Simcox J, Nagy LE, Brown JM. Varadharajan V, et al. Among authors: simcox j. Elife. 2024 Apr 22;12:RP92243. doi: 10.7554/eLife.92243. Elife. 2024. PMID: 38648183 Free PMC article.
Dietary lipid is largely deposited in skin and rapidly affects insulating properties.
Riley N, Kasza I, Barrett-Wilt G, Michaud J, Jain R, Trautman ME, Simcox JA, Yen CE, MacDougald OA, Lamming DW, Alexander CM. Riley N, et al. Among authors: simcox ja. Res Sq [Preprint]. 2024 Feb 22:rs.3.rs-3957002. doi: 10.21203/rs.3.rs-3957002/v1. Res Sq. 2024. PMID: 38464106 Free PMC article. Preprint.
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism.
Rashan EH, Bartlett AK, Khana DB, Zhang J, Jain R, Smith AJ, Baker ZN, Cook T, Caldwell A, Chevalier AR, Pfleger BF, Yuan P, Amador-Noguez D, Simcox JA, Pagliarini DJ. Rashan EH, et al. Among authors: simcox ja. bioRxiv [Preprint]. 2024 Jan 9:2024.01.09.574893. doi: 10.1101/2024.01.09.574893. bioRxiv. 2024. PMID: 38260250 Free PMC article. Preprint.
Modulation of hepatic transcription factor EB activity during cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by Pla2g15.
Jain R, Geoghegan G, Davidson J, Nesbitt DJ, Abe A, Chao X, James I, Cavanagh A, Michorowska S, Verma R, Scheuler K, Hinkovska-Galcheva V, Shishkova E, Ding WX, Coon JJ, Shayman JA, Simcox JA. Jain R, et al. Among authors: simcox ja. bioRxiv [Preprint]. 2023 Nov 10:2023.11.03.565498. doi: 10.1101/2023.11.03.565498. bioRxiv. 2023. PMID: 37986778 Free PMC article. Preprint.
Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury.
Varadharajan V, Ramachandiran L, Massey WJ, Jain R, Banerjee R, Horak AJ, McMullen MR, Huang E, Bellar A, Lorkowski SW, Guilshan K, Helsley RN, James I, Pathak V, Dasarathy J, Welch N, Dasarathy S, Streem D, Reizes O, Allende DS, Smith JD, Simcox J, Nagy LE, Brown JM. Varadharajan V, et al. Among authors: simcox j. bioRxiv [Preprint]. 2024 Jan 10:2023.09.26.559533. doi: 10.1101/2023.09.26.559533. bioRxiv. 2024. PMID: 37808828 Free PMC article. Updated. Preprint.
Protein restriction slows the development and progression of Alzheimer's disease in mice.
Babygirija R, Sonsalla MM, Mill J, James I, Han JH, Green CL, Calubag MF, Wade G, Tobon A, Michael J, Trautman MM, Matoska R, Yeh CY, Grunow I, Pak HH, Rigby MJ, Baldwin DA, Niemi NM, Denu JM, Puglielli L, Simcox J, Lamming DW. Babygirija R, et al. Among authors: simcox j. Res Sq [Preprint]. 2024 Apr 24:rs.3.rs-3342413. doi: 10.21203/rs.3.rs-3342413/v1. Res Sq. 2024. PMID: 37790423 Free PMC article. Preprint.
43 results