Freitas JR - Search Results

1

FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design.

Ng WH, Liu X, Ling ZL, Santos CNO, Magalhães LS, Kueh AJ, Herold MJ, Taylor A, Freitas JR, Koit S, Wang S, Lloyd AR, Teixeira MM, Merits A, Almeida RP, King NJC, Mahalingam S. Ng WH, et al. Among authors: freitas jr. Nat Commun. 2023 Oct 26;14(1):6605. doi: 10.1038/s41467-023-42330-2. Nat Commun. 2023. PMID: 37884534 Free PMC article.

2

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S. Chen W, et al. Among authors: freitas jr. Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28. Nat Microbiol. 2017. PMID: 28848230

3

Attenuation and Stability of CHIKV-NoLS, a Live-Attenuated Chikungunya Virus Vaccine Candidate.

Abeyratne E, Freitas JR, Zaid A, Mahalingam S, Taylor A. Abeyratne E, et al. Among authors: freitas jr. Vaccines (Basel). 2018 Dec 22;7(1):2. doi: 10.3390/vaccines7010002. Vaccines (Basel). 2018. PMID: 30583514 Free PMC article.

4

Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX₃CR1⁺ Macrophages in Tissue Repair.

Zaid A, Tharmarajah K, Mostafavi H, Freitas JR, Sheng KC, Foo SS, Chen W, Vider J, Liu X, West NP, Herrero LJ, Taylor A, Mackay LK, Getts DR, King NJC, Mahalingam S. Zaid A, et al. Among authors: freitas jr. mBio. 2020 Mar 3;11(2):e03353-19. doi: 10.1128/mBio.03353-19. mBio. 2020. PMID: 32127460 Free PMC article.

5

The Delta SARS-CoV-2 Variant of Concern Induces Distinct Pathogenic Patterns of Respiratory Disease in K18-hACE2 Transgenic Mice Compared to the Ancestral Strain from Wuhan.

Liu X, Mostafavi H, Ng WH, Freitas JR, King NJC, Zaid A, Taylor A, Mahalingam S. Liu X, et al. Among authors: freitas jr. mBio. 2022 Jun 28;13(3):e0068322. doi: 10.1128/mbio.00683-22. Epub 2022 Apr 14. mBio. 2022. PMID: 35420469 Free PMC article.

6

A booster regime of liposome-delivered live-attenuated CHIKV vaccine RNA genome protects against chikungunya virus disease in mice.

Rao S, Abeyratne E, Freitas JR, Yang C, Tharmarajah K, Mostafavi H, Liu X, Zaman M, Mahalingam S, Zaid A, Taylor A. Rao S, et al. Among authors: freitas jr. Vaccine. 2023 Jun 19;41(27):3976-3988. doi: 10.1016/j.vaccine.2023.05.032. Epub 2023 May 23. Vaccine. 2023. PMID: 37230889 Free article.

7

Liposomal Delivery of the RNA Genome of a Live-Attenuated Chikungunya Virus Vaccine Candidate Provides Local, but Not Systemic Protection After One Dose.

Abeyratne E, Tharmarajah K, Freitas JR, Mostafavi H, Mahalingam S, Zaid A, Zaman M, Taylor A. Abeyratne E, et al. Among authors: freitas jr. Front Immunol. 2020 Mar 5;11:304. doi: 10.3389/fimmu.2020.00304. eCollection 2020. Front Immunol. 2020. PMID: 32194557 Free PMC article.

8

Interleukin-17 contributes to Ross River virus-induced arthritis and myositis.

Mostafavi H, Tharmarajah K, Vider J, West NP, Freitas JR, Cameron B, Foster PS, Hueston LP, Lloyd AR, Mahalingam S, Zaid A. Mostafavi H, et al. Among authors: freitas jr. PLoS Pathog. 2022 Feb 10;18(2):e1010185. doi: 10.1371/journal.ppat.1010185. eCollection 2022 Feb. PLoS Pathog. 2022. PMID: 35143591 Free PMC article.

9

N-Linked Glycans Shape Skin Immune Responses during Arthritis and Myositis after Intradermal Infection with Ross River Virus.

Tharmarajah K, Everest-Dass A, Vider J, Liu X, Freitas JR, Mostafavi H, Bettadapura J, von Itzstein M, West NP, Taylor A, Mahalingam S, Zaid A. Tharmarajah K, et al. Among authors: freitas jr. J Virol. 2022 Sep 14;96(17):e0099922. doi: 10.1128/jvi.00999-22. Epub 2022 Aug 24. J Virol. 2022. PMID: 36000846 Free PMC article.

10

Infectious Clones Produce SARS-CoV-2 That Causes Severe Pulmonary Disease in Infected K18-Human ACE2 Mice.

Liu X, Zaid A, Freitas JR, McMillan NA, Mahalingam S, Taylor A. Liu X, et al. Among authors: freitas jr. mBio. 2021 Apr 20;12(2):e00819-21. doi: 10.1128/mBio.00819-21. mBio. 2021. PMID: 33879586 Free PMC article.

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