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DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity.
Wichroski M, Benci J, Liu SQ, Chupak L, Fang J, Cao C, Wang C, Onorato J, Qiu H, Shan Y, Banas D, Powles R, Locke G, Witt A, Stromko C, Qi H, Zheng X, Martin S, Ding M, Gentles R, Meanwell N, Velaparthi U, Olson R, Wee S, Tenney D, Parker CG, Cravatt BF, Lawrence M, Borzilleri R, Lees E. Wichroski M, et al. Among authors: benci j. Sci Transl Med. 2023 Oct 25;15(719):eadh1892. doi: 10.1126/scitranslmed.adh1892. Epub 2023 Oct 25. Sci Transl Med. 2023. PMID: 37878674
A multi-omic single cell sequencing approach to develop a CD8 T cell specific gene signature for anti-PD1 response in solid tumors.
Kumar N, Papillon-Cavanagh S, Tang H, Wang S, Stromko C, Ho CP, Soni-Sheth S, Vasquez-Grinnell S, Broz ML, Tenney DJ, Wichroski MJ, Walsh AM, Hu Y, Benci JL. Kumar N, et al. Among authors: benci jl. Int J Cancer. 2022 Dec 1;151(11):2043-2054. doi: 10.1002/ijc.34218. Epub 2022 Aug 6. Int J Cancer. 2022. PMID: 35932450 Free article.
PIM kinases as therapeutic targets against advanced melanoma.
Shannan B, Watters A, Chen Q, Mollin S, Dörr M, Meggers E, Xu X, Gimotty PA, Perego M, Li L, Benci J, Krepler C, Brafford P, Zhang J, Wei Z, Zhang G, Liu Q, Yin X, Nathanson KL, Herlyn M, Vultur A. Shannan B, et al. Among authors: benci j. Oncotarget. 2016 Aug 23;7(34):54897-54912. doi: 10.18632/oncotarget.10703. Oncotarget. 2016. PMID: 27448973 Free PMC article.
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ. Twyman-Saint Victor C, et al. Among authors: benci jl. Nature. 2015 Apr 16;520(7547):373-7. doi: 10.1038/nature14292. Epub 2015 Mar 9. Nature. 2015. PMID: 25754329 Free PMC article.
20 results