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CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia.
Hirani DV, Thielen F, Mansouri S, Danopoulos S, Vohlen C, Haznedar-Karakaya P, Mohr J, Wilke R, Selle J, Grosch T, Mizik I, Odenthal M, Alvira CM, Kuiper-Makris C, Pryhuber GS, Pallasch C, van Koningsbruggen-Rietschel S, Al-Alam D, Seeger W, Savai R, Dötsch J, Alejandre Alcazar MA. Hirani DV, et al. Inflamm Regen. 2023 Oct 24;43(1):52. doi: 10.1186/s41232-023-00301-6. Inflamm Regen. 2023. PMID: 37876024 Free PMC article.
Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia.
Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, V Koningsbruggen-Rietschel S, Barbarino V, Pallasch C, Rose-John S, Odenthal M, Pryhuber GS, Mansouri S, Savai R, Seeger W, Khatri P, Al Alam D, Dötsch J, Alejandre Alcazar MA. Hirani D, et al. Eur Respir J. 2022 Feb 17;59(2):2002248. doi: 10.1183/13993003.02248-2020. Print 2022 Feb. Eur Respir J. 2022. PMID: 34446466 Free PMC article.
Novel functional role of GH/IGF-I in neonatal lung myofibroblasts and in rat lung growth after intrauterine growth restriction.
Nawabi J, Vohlen C, Dinger K, Thangaratnarajah C, Klaudt C, Lopez Garcia E, Hirani DV, Karakaya PH, Macheleidt I, Odenthal M, Nüsken KD, Dötsch J, Alejandre Alcazar MA. Nawabi J, et al. Among authors: hirani dv. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L623-L637. doi: 10.1152/ajplung.00413.2017. Epub 2018 Jul 26. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 30047284 Free article.
Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life.
Selle J, Dinger K, Jentgen V, Zanetti D, Will J, Georgomanolis T, Vohlen C, Wilke R, Kojonazarov B, Klymenko O, Mohr J, V Koningsbruggen-Rietschel S, Rhodes CJ, Ulrich A, Hirani D, Nestler T, Odenthal M, Mahabir E, Nayakanti S, Dabral S, Wunderlich T, Priest J, Seeger W, Dötsch J, Pullamsetti SS, Alejandre Alcazar MA. Selle J, et al. Nat Commun. 2022 Jul 27;13(1):4352. doi: 10.1038/s41467-022-31655-z. Nat Commun. 2022. PMID: 35896539 Free PMC article.
Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice.
Alejandre Alcazar MA, Kaschwich M, Ertsey R, Preuss S, Milla C, Mujahid S, Masumi J, Khan S, Mokres LM, Tian L, Mohr J, Hirani DV, Rabinovitch M, Bland RD. Alejandre Alcazar MA, et al. Among authors: hirani dv. Am J Respir Cell Mol Biol. 2018 Nov;59(5):623-634. doi: 10.1165/rcmb.2017-0332OC. Am J Respir Cell Mol Biol. 2018. PMID: 29894205 Free PMC article.