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Activation of Gcn2 by small molecules designed to be inhibitors.
Carlson KR, Georgiadis MM, Tameire F, Staschke KA, Wek RC. Carlson KR, et al. Among authors: wek rc. J Biol Chem. 2023 Apr;299(4):104595. doi: 10.1016/j.jbc.2023.104595. Epub 2023 Mar 8. J Biol Chem. 2023. PMID: 36898579 Free PMC article.
Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones.
Koppes EA, Johnson MA, Moresco JJ, Luppi P, Lewis DW, Stolz DB, Diedrich JK, Yates JR 3rd, Wek RC, Watkins SC, Gollin SM, Park HJ, Drain P, Nicholls RD. Koppes EA, et al. Among authors: wek rc. PLoS Genet. 2023 Apr 17;19(4):e1010710. doi: 10.1371/journal.pgen.1010710. eCollection 2023 Apr. PLoS Genet. 2023. PMID: 37068109 Free PMC article.
GCN2 is required to maintain core body temperature in mice during acute cold.
Levy JL, Mirek ET, Rodriguez EM, Zalma B, Burns J, Jonsson WO, Sampath H, Staschke KA, Wek RC, Anthony TG. Levy JL, et al. Among authors: wek rc. Am J Physiol Endocrinol Metab. 2023 Nov 1;325(5):E624-E637. doi: 10.1152/ajpendo.00181.2023. Epub 2023 Oct 4. Am J Physiol Endocrinol Metab. 2023. PMID: 37792040 Free PMC article.
156 results