Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood-brain barrier in mice.
Han EC, Choi SY, Lee Y, Park JW, Hong SH, Lee HJ.
Han EC, et al. Among authors: lee y, lee hj.
FASEB J. 2019 Dec;33(12):13412-13422. doi: 10.1096/fj.201901575R. Epub 2019 Sep 21.
FASEB J. 2019.
PMID: 31545910
Free PMC article.
The current study indicates that host gene regulation by microRNAs originating from OMVs of the periodontal pathogen Aa is a novel mechanism for host gene regulation and that the transfer of OMV exRNAs to the brain may cause neuroinflammatory diseases like Alzheimer's.-Han, E.-C. …
The current study indicates that host gene regulation by microRNAs originating from OMVs of the periodontal pathogen Aa is a novel mechanism …