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High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.
Gruber T, Lechner F, Murat C, Contreras RE, Sanchez-Quant E, Miok V, Makris K, Le Thuc O, González-García I, García-Clave E, Althammer F, Krabichler Q, DeCamp LM, Jones RG, Lutter D, Williams RH, Pfluger PT, Müller TD, Woods SC, Pospisilik JA, Martinez-Jimenez CP, Tschöp MH, Grinevich V, García-Cáceres C. Gruber T, et al. Among authors: pfluger pt. Cell Rep. 2023 Oct 31;42(10):113305. doi: 10.1016/j.celrep.2023.113305. Cell Rep. 2023. PMID: 37864798 Free PMC article.
The central melanocortin system directly controls peripheral lipid metabolism.
Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH. Nogueiras R, et al. Among authors: pfluger pt. J Clin Invest. 2007 Nov;117(11):3475-88. doi: 10.1172/JCI31743. J Clin Invest. 2007. PMID: 17885689 Free PMC article.
Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability.
Nogueiras R, López M, Lage R, Perez-Tilve D, Pfluger P, Mendieta-Zerón H, Sakkou M, Wiedmer P, Benoit SC, Datta R, Dong JZ, Culler M, Sleeman M, Vidal-Puig A, Horvath T, Treier M, Diéguez C, Tschöp MH. Nogueiras R, et al. Endocrinology. 2008 Jun;149(6):3009-15. doi: 10.1210/en.2007-1684. Epub 2008 Feb 28. Endocrinology. 2008. PMID: 18308842 Free PMC article.
Gastric O-acyl transferase activates hunger signal to the brain.
Tong J, Pfluger PT, Tschöp MH. Tong J, et al. Among authors: pfluger pt. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6213-4. doi: 10.1073/pnas.0802461105. Epub 2008 Apr 28. Proc Natl Acad Sci U S A. 2008. PMID: 18443299 Free PMC article. No abstract available.
Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats.
Strassburg S, Anker SD, Castaneda TR, Burget L, Perez-Tilve D, Pfluger PT, Nogueiras R, Halem H, Dong JZ, Culler MD, Datta R, Tschöp MH. Strassburg S, et al. Among authors: pfluger pt. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E78-84. doi: 10.1152/ajpendo.00040.2008. Epub 2008 May 6. Am J Physiol Endocrinol Metab. 2008. PMID: 18460598 Free PMC article.
124 results