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PRMT5 Inhibitors Regulate DNA Damage Repair Pathways in Cancer Cells and Improve Response to PARP Inhibition and Chemotherapies.
Carter J, Hulse M, Sivakumar M, Burtell J, Thodima V, Wang M, Agarwal A, Vykuntam K, Spruance J, Bhagwat N, Rager J, Ruggeri B, Scherle P, Ito K. Carter J, et al. Among authors: spruance j. Cancer Res Commun. 2023 Nov 6;3(11):2233-2243. doi: 10.1158/2767-9764.CRC-23-0070. Cancer Res Commun. 2023. PMID: 37861290 Free PMC article.
Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.
Bartholf DeWitt S, Hoskinson Plumlee S, Brighton HE, Sivaraj D, Martz EJ, Zand M, Kumar V, Sheth MU, Floyd W, Spruance JV, Hawkey N, Varghese S, Ruan J, Kirsch DG, Somarelli JA, Alman B, Eward WC. Bartholf DeWitt S, et al. Among authors: spruance jv. JCI Insight. 2022 Sep 8;7(17):e151583. doi: 10.1172/jci.insight.151583. JCI Insight. 2022. PMID: 36073547 Free PMC article.
An integrated comparative physiology and molecular approach pinpoints mediators of breath-hold capacity in dolphins.
Blawas AM, Ware KE, Schmaltz E, Zheng L, Spruance J, Allen AS, West N, Devos N, Corcoran DL, Nowacek DP, Eward WC, Fahlman A, Somarelli JA. Blawas AM, et al. Among authors: spruance j. Evol Med Public Health. 2021 Oct 28;9(1):420-430. doi: 10.1093/emph/eoab036. eCollection 2021. Evol Med Public Health. 2021. PMID: 35169481 Free PMC article.