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Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury.
Fuentes-Flores A, Geronimo-Olvera C, Girardi K, Necuñir-Ibarra D, Patel SK, Bons J, Wright MC, Geschwind D, Hoke A, Gomez-Sanchez JA, Schilling B, Rebolledo DL, Campisi J, Court FA. Fuentes-Flores A, et al. Among authors: geschwind d. EMBO Mol Med. 2023 Dec 7;15(12):e17907. doi: 10.15252/emmm.202317907. Epub 2023 Oct 20. EMBO Mol Med. 2023. PMID: 37860842 Free PMC article.
Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.
Schmitd LB, Hafner H, Ward A, Asghari Adib E, Biscola NP, Kohen R, Patel M, Williamson RE, Desai E, Bennett J, Saxman G, Athaiya M, Wilborn D, Shumpert J, Zhao XF, Kawaguchi R, Geschwind DH, Hoke A, Shrager P, Collins CA, Havton LA, Kalinski AL, Giger RJ. Schmitd LB, et al. Among authors: geschwind dh. bioRxiv [Preprint]. 2024 Apr 17:2024.03.04.583374. doi: 10.1101/2024.03.04.583374. bioRxiv. 2024. PMID: 38496662 Free PMC article. Preprint.
Distinct Patterns of Gene Expression Changes in the Colon and Striatum of Young Mice Overexpressing Alpha-Synuclein Support Parkinson's Disease as a Multi-System Process.
Videlock EJ, Hatami A, Zhu C, Kawaguchi R, Chen H, Khan T, Yehya AHS, Stiles L, Joshi S, Hoffman JM, Law KM, Rankin CR, Chang L, Maidment NT, John V, Geschwind DH, Pothoulakis C. Videlock EJ, et al. J Parkinsons Dis. 2023;13(7):1127-1147. doi: 10.3233/JPD-223568. J Parkinsons Dis. 2023. PMID: 37638450 Free PMC article.
Massively parallel characterization of regulatory elements in the developing human cortex.
Deng C, Whalen S, Steyert M, Ziffra R, Przytycki PF, Inoue F, Pereira DA, Capauto D, Norton S, Vaccarino FM; PsychENCODE Consortium‡; Pollen AA, Nowakowski TJ, Ahituv N, Pollard KS; PsychENCODE Consortium. Deng C, et al. Science. 2024 May 24;384(6698):eadh0559. doi: 10.1126/science.adh0559. Epub 2024 May 24. Science. 2024. PMID: 38781390
693 results