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Structure of LRRK1 and mechanisms of autoinhibition and activation.
Reimer JM, Dickey AM, Lin YX, Abrisch RG, Mathea S, Chatterjee D, Fay EJ, Knapp S, Daugherty MD, Reck-Peterson SL, Leschziner AE. Reimer JM, et al. Among authors: mathea s. Nat Struct Mol Biol. 2023 Nov;30(11):1735-1745. doi: 10.1038/s41594-023-01109-1. Epub 2023 Oct 19. Nat Struct Mol Biol. 2023. PMID: 37857821 Free PMC article.
Isoform-specific inhibition of cyclophilins.
Daum S, Schumann M, Mathea S, Aumüller T, Balsley MA, Constant SL, de Lacroix BF, Kruska F, Braun M, Schiene-Fischer C. Daum S, et al. Among authors: mathea s. Biochemistry. 2009 Jul 7;48(26):6268-77. doi: 10.1021/bi9007287. Biochemistry. 2009. PMID: 19480458 Free PMC article.
Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.
Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S. Mathea S, et al. ACS Chem Biol. 2016 Jun 17;11(6):1595-602. doi: 10.1021/acschembio.6b00043. Epub 2016 Mar 31. ACS Chem Biol. 2016. PMID: 26999302 Free PMC article.
Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.
Gebel J, Luh LM, Coutandin D, Osterburg C, Löhr F, Schäfer B, Frombach AS, Sumyk M, Buchner L, Krojer T, Salah E, Mathea S, Güntert P, Knapp S, Dötsch V. Gebel J, et al. Among authors: mathea s. Cell Death Differ. 2016 Dec;23(12):1930-1940. doi: 10.1038/cdd.2016.83. Epub 2016 Oct 7. Cell Death Differ. 2016. PMID: 27716744 Free PMC article.
A Pseudo-Kinase Double Act.
Preuß F, Mathea S, Knapp S. Preuß F, et al. Among authors: mathea s. Structure. 2018 Apr 3;26(4):527-528. doi: 10.1016/j.str.2018.03.008. Structure. 2018. PMID: 29617648 Free article.
A Pseudo-Kinase Double Act.
Preuß F, Mathea S, Knapp S. Preuß F, et al. Among authors: mathea s. Structure. 2018 Nov 6;26(11):1564. doi: 10.1016/j.str.2018.10.019. Structure. 2018. PMID: 30403994 Free article. No abstract available.
Lessons from LIMK1 enzymology and their impact on inhibitor design.
Salah E, Chatterjee D, Beltrami A, Tumber A, Preuss F, Canning P, Chaikuad A, Knaus P, Knapp S, Bullock AN, Mathea S. Salah E, et al. Among authors: mathea s. Biochem J. 2019 Nov 15;476(21):3197-3209. doi: 10.1042/BCJ20190517. Biochem J. 2019. PMID: 31652302 Free PMC article.
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Sheetz JB, Mathea S, Karvonen H, Malhotra K, Chatterjee D, Niininen W, Perttilä R, Preuss F, Suresh K, Stayrook SE, Tsutsui Y, Radhakrishnan R, Ungureanu D, Knapp S, Lemmon MA. Sheetz JB, et al. Among authors: mathea s. Mol Cell. 2020 Aug 6;79(3):390-405.e7. doi: 10.1016/j.molcel.2020.06.018. Epub 2020 Jul 2. Mol Cell. 2020. PMID: 32619402 Free PMC article.
39 results