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CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells.
Samain R, Maiques O, Monger J, Lam H, Candido J, George S, Ferrari N, KohIhammer L, Lunetto S, Varela A, Orgaz JL, Vilardell F, Olsina JJ, Matias-Guiu X, Sarker D, Biddle A, Balkwill FR, Eyles J, Wilkinson RW, Kocher HM, Calvo F, Wells CM, Sanz-Moreno V. Samain R, et al. Among authors: wilkinson rw. Sci Adv. 2023 Oct 20;9(42):eadi0244. doi: 10.1126/sciadv.adi0244. Epub 2023 Oct 18. Sci Adv. 2023. PMID: 37851808 Free PMC article.
A B7-H4-Targeting Antibody-Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression.
Gitto SB, Whicker M, Davies G, Kumar S, Kinneer K, Xu H, Lewis A, Mamidi S, Medvedev S, Kim H, Anderton J, Tang EJ, Ferman B, Coats S, Wilkinson RW, Brown E, Powell DJ Jr, Simpkins F. Gitto SB, et al. Among authors: wilkinson rw. Clin Cancer Res. 2024 Apr 15;30(8):1567-1581. doi: 10.1158/1078-0432.CCR-23-1079. Clin Cancer Res. 2024. PMID: 37882675
Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma.
Egan D, Kreileder M, Nabhan M, Iglesias-Martinez LF, Dovedi SJ, Valge-Archer V, Grover A, Wilkinson RW, Slidel T, Bendtsen C, Barrett IP, Brennan DJ, Kolch W, Zhernovkov V. Egan D, et al. Among authors: wilkinson rw. Cancer Immunol Res. 2023 Aug 3;11(8):1125-1136. doi: 10.1158/2326-6066.CIR-22-0563. Cancer Immunol Res. 2023. PMID: 37229623 Free PMC article.
Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models.
Kaistha BP, Kar G, Dannhorn A, Watkins A, Opoku-Ansah G, Ilieva K, Mullins S, Anderton J, Galvani E, Garcon F, Lapointe JM, Brown L, Hair J, Slidel T, Luheshi N, Ryan K, Hardaker E, Dovedi S, Kumar R, Wilkinson RW, Hammond SA, Eyles J. Kaistha BP, et al. Among authors: wilkinson rw. Cancer Biol Ther. 2024 Dec 31;25(1):2296048. doi: 10.1080/15384047.2023.2296048. Epub 2024 Jan 11. Cancer Biol Ther. 2024. PMID: 38206570 Free PMC article.
Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation.
Lopez-Pelaez M, Young L, Vazquez-Chantada M, Nelson N, Durant S, Wilkinson RW, Poon E, Gaspar M, Valge-Archer V, Smith P, Dovedi SJ. Lopez-Pelaez M, et al. Among authors: wilkinson rw. Oncoimmunology. 2022 Sep 13;11(1):2117321. doi: 10.1080/2162402X.2022.2117321. eCollection 2022. Oncoimmunology. 2022. PMID: 36117525 Free PMC article.
Recombinant Newcastle Disease Virus Immunotherapy Drives Oncolytic Effects and Durable Systemic Antitumor Immunity.
Harper J, Burke S, Travers J, Rath N, Leinster A, Navarro C, Franks R, Leyland R, Mulgrew K, McGlinchey K, Brown L, Dovedi SJ, Koopmann JO, Durham NM, Cheng X, Jin H, Eyles J, Wilkinson RW, Carroll D. Harper J, et al. Among authors: wilkinson rw. Mol Cancer Ther. 2021 Sep;20(9):1723-1734. doi: 10.1158/1535-7163.MCT-20-0902. Epub 2021 Jun 17. Mol Cancer Ther. 2021. PMID: 34224361 Free PMC article.
Novel non-terminal tumor sampling procedure using fine needle aspiration supports immuno-oncology biomarker discovery in preclinical mouse models.
Sitnikova SI, Munnings-Tomes S, Galvani E, Kentner S, Mulgrew K, Rands C, España Agustí J, Zhang T, Ilieva KM, Rosignoli G, Ghadially H, Robinson MJ, Slidel T, Wilkinson RW, Dovedi SJ. Sitnikova SI, et al. Among authors: wilkinson rw. J Immunother Cancer. 2021 Jun;9(6):e002894. doi: 10.1136/jitc-2021-002894. J Immunother Cancer. 2021. PMID: 34145033 Free PMC article.
Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells.
Dovedi SJ, Elder MJ, Yang C, Sitnikova SI, Irving L, Hansen A, Hair J, Jones DC, Hasani S, Wang B, Im SA, Tran B, Subramaniam DS, Gainer SD, Vashisht K, Lewis A, Jin X, Kentner S, Mulgrew K, Wang Y, Overstreet MG, Dodgson J, Wu Y, Palazon A, Morrow M, Rainey GJ, Browne GJ, Neal F, Murray TV, Toloczko AD, Dall'Acqua W, Achour I, Freeman DJ, Wilkinson RW, Mazor Y. Dovedi SJ, et al. Among authors: wilkinson rw. Cancer Discov. 2021 May;11(5):1100-1117. doi: 10.1158/2159-8290.CD-20-1445. Epub 2021 Jan 8. Cancer Discov. 2021. PMID: 33419761
98 results