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Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.
Verbrugge SE, Al M, Assaraf YG, Kammerer S, Chandrupatla DM, Honeywell R, Musters RP, Giovannetti E, O'Toole T, Scheffer GL, Krige D, de Gruijl TD, Niessen HW, Lems WF, Kramer PA, Scheper RJ, Cloos J, Ossenkoppele GJ, Peters GJ, Jansen G. Verbrugge SE, et al. Among authors: assaraf yg. Oncotarget. 2016 Feb 2;7(5):5240-57. doi: 10.18632/oncotarget.6169. Oncotarget. 2016. PMID: 26496029 Free PMC article.
Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.
Wojtuszkiewicz A, Schuurhuis GJ, Kessler FL, Piersma SR, Knol JC, Pham TV, Jansen G, Musters RJ, van Meerloo J, Assaraf YG, Kaspers GJ, Zweegman S, Cloos J, Jimenez CR. Wojtuszkiewicz A, et al. Among authors: assaraf yg. Mol Cell Proteomics. 2016 Apr;15(4):1281-98. doi: 10.1074/mcp.M115.052944. Epub 2016 Jan 22. Mol Cell Proteomics. 2016. PMID: 26801919 Free PMC article.
Exocytosis of polyubiquitinated proteins in bortezomib-resistant leukemia cells: a role for MARCKS in acquired resistance to proteasome inhibitors.
Franke NE, Kaspers GL, Assaraf YG, van Meerloo J, Niewerth D, Kessler FL, Poddighe PJ, Kole J, Smeets SJ, Ylstra B, Bi C, Chng WJ, Horton TM, Menezes RX, Musters RJ, Zweegman S, Jansen G, Cloos J. Franke NE, et al. Among authors: assaraf yg. Oncotarget. 2016 Nov 15;7(46):74779-74796. doi: 10.18632/oncotarget.11340. Oncotarget. 2016. PMID: 27542283 Free PMC article.
The role of alternative splicing in cancer: From oncogenesis to drug resistance.
Sciarrillo R, Wojtuszkiewicz A, Assaraf YG, Jansen G, Kaspers GJL, Giovannetti E, Cloos J. Sciarrillo R, et al. Among authors: assaraf yg. Drug Resist Updat. 2020 Dec;53:100728. doi: 10.1016/j.drup.2020.100728. Epub 2020 Sep 28. Drug Resist Updat. 2020. PMID: 33070093 Free article. Review.
237 results