Scrutton NS - Search Results

1

Decoding Catalysis by Terpene Synthases.

Whitehead JN, Leferink NGH, Johannissen LO, Hay S, Scrutton NS. Whitehead JN, et al. Among authors: scrutton ns. ACS Catal. 2023 Sep 15;13(19):12774-12802. doi: 10.1021/acscatal.3c03047. eCollection 2023 Oct 6. ACS Catal. 2023. PMID: 37822860 Free PMC article. Review.

2

Atomic description of an enzyme reaction dominated by proton tunneling.

Masgrau L, Roujeinikova A, Johannissen LO, Hothi P, Basran J, Ranaghan KE, Mulholland AJ, Sutcliffe MJ, Scrutton NS, Leys D. Masgrau L, et al. Among authors: scrutton ns. Science. 2006 Apr 14;312(5771):237-41. doi: 10.1126/science.1126002. Science. 2006. PMID: 16614214

3

Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems.

Sutcliffe MJ, Masgrau L, Roujeinikova A, Johannissen LO, Hothi P, Basran J, Ranaghan KE, Mulholland AJ, Leys D, Scrutton NS. Sutcliffe MJ, et al. Among authors: scrutton ns. Philos Trans R Soc Lond B Biol Sci. 2006 Aug 29;361(1472):1375-86. doi: 10.1098/rstb.2006.1878. Philos Trans R Soc Lond B Biol Sci. 2006. PMID: 16873125 Free PMC article. Review.

4

Alpha-secondary isotope effects as probes of "tunneling-ready" configurations in enzymatic H-tunneling: insight from environmentally coupled tunneling models.

Pudney CR, Hay S, Sutcliffe MJ, Scrutton NS. Pudney CR, et al. Among authors: scrutton ns. J Am Chem Soc. 2006 Nov 1;128(43):14053-8. doi: 10.1021/ja0614619. J Am Chem Soc. 2006. PMID: 17061887

5

Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects.

Hay S, Sutcliffe MJ, Scrutton NS. Hay S, et al. Among authors: scrutton ns. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):507-12. doi: 10.1073/pnas.0608408104. Epub 2007 Jan 3. Proc Natl Acad Sci U S A. 2007. PMID: 17202258 Free PMC article.

6

Proton tunneling in aromatic amine dehydrogenase is driven by a short-range sub-picosecond promoting vibration: consistency of simulation and theory with experiment.

Johannissen LO, Hay S, Scrutton NS, Sutcliffe MJ. Johannissen LO, et al. Among authors: scrutton ns. J Phys Chem B. 2007 Mar 15;111(10):2631-8. doi: 10.1021/jp066276w. Epub 2007 Feb 17. J Phys Chem B. 2007. PMID: 17305385

7

Conformational and thermodynamic control of electron transfer in neuronal nitric oxide synthase.

Dunford AJ, Rigby SE, Hay S, Munro AW, Scrutton NS. Dunford AJ, et al. Among authors: scrutton ns. Biochemistry. 2007 May 1;46(17):5018-29. doi: 10.1021/bi7001339. Epub 2007 Apr 6. Biochemistry. 2007. PMID: 17411075

8

Conformational dynamics of the cytochrome P450 BM3/N-palmitoylglycine complex: the proposed "proximal-distal" transition probed by temperature-jump spectroscopy.

Brenner S, Hay S, Girvan HM, Munro AW, Scrutton NS. Brenner S, et al. Among authors: scrutton ns. J Phys Chem B. 2007 Jul 12;111(27):7879-86. doi: 10.1021/jp073036n. Epub 2007 Jun 16. J Phys Chem B. 2007. PMID: 17571881

9

DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis.

Gong M, Hay S, Marshall KR, Munro AW, Scrutton NS. Gong M, et al. Among authors: scrutton ns. J Biol Chem. 2007 Oct 12;282(41):30331-40. doi: 10.1074/jbc.M703713200. Epub 2007 Aug 20. J Biol Chem. 2007. PMID: 17711848 Free article.

10

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms.

Pudney CR, Hay S, Pang J, Costello C, Leys D, Sutcliffe MJ, Scrutton NS. Pudney CR, et al. Among authors: scrutton ns. J Am Chem Soc. 2007 Nov 14;129(45):13949-56. doi: 10.1021/ja074463h. Epub 2007 Oct 16. J Am Chem Soc. 2007. PMID: 17939663

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