Arosio P - Search Results

1

A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models.

Wirth F, Heitz FD, Seeger C, Combaluzier I, Breu K, Denroche HC, Thevenet J, Osto M, Arosio P, Kerr-Conte J, Verchere CB, Pattou F, Lutz TA, Donath MY, Hock C, Nitsch RM, Grimm J. Wirth F, et al. Among authors: arosio p. Nat Commun. 2023 Oct 9;14(1):6294. doi: 10.1038/s41467-023-41986-0. Nat Commun. 2023. PMID: 37813862 Free PMC article.

2

Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice.

Ni R, Chen Z, Deán-Ben XL, Voigt FF, Kirschenbaum D, Shi G, Villois A, Zhou Q, Crimi A, Arosio P, Nitsch RM, Nilsson KPR, Aguzzi A, Helmchen F, Klohs J, Razansky D. Ni R, et al. Among authors: arosio p. Nat Biomed Eng. 2022 Sep;6(9):1031-1044. doi: 10.1038/s41551-022-00906-1. Epub 2022 Jul 14. Nat Biomed Eng. 2022. PMID: 35835994 Free article.

3

Local environment in biomolecular condensates modulates enzymatic activity across length scales.

Gil-Garcia M, Benítez-Mateos AI, Papp M, Stoffel F, Morelli C, Normak K, Makasewicz K, Faltova L, Paradisi F, Arosio P. Gil-Garcia M, et al. Among authors: arosio p. Nat Commun. 2024 Apr 18;15(1):3322. doi: 10.1038/s41467-024-47435-w. Nat Commun. 2024. PMID: 38637545 Free PMC article.

4

Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity.

Linsenmeier M, Hondele M, Grigolato F, Secchi E, Weis K, Arosio P. Linsenmeier M, et al. Among authors: arosio p. Nat Commun. 2022 May 31;13(1):3030. doi: 10.1038/s41467-022-30521-2. Nat Commun. 2022. PMID: 35641495 Free PMC article.

5

RNA modulates hnRNPA1A amyloid formation mediated by biomolecular condensates.

Morelli C, Faltova L, Capasso Palmiero U, Makasewicz K, Papp M, Jacquat RPB, Pinotsi D, Arosio P. Morelli C, et al. Among authors: arosio p. Nat Chem. 2024 Mar 12. doi: 10.1038/s41557-024-01467-3. Online ahead of print. Nat Chem. 2024. PMID: 38472406

6

Non-specificity as the sticky problem in therapeutic antibody development.

Ausserwöger H, Schneider MM, Herling TW, Arosio P, Invernizzi G, Knowles TPJ, Lorenzen N. Ausserwöger H, et al. Among authors: arosio p. Nat Rev Chem. 2022 Dec;6(12):844-861. doi: 10.1038/s41570-022-00438-x. Epub 2022 Nov 14. Nat Rev Chem. 2022. PMID: 37117703 Review.

7

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation.

Arosio P, Michaels TC, Linse S, Månsson C, Emanuelsson C, Presto J, Johansson J, Vendruscolo M, Dobson CM, Knowles TP. Arosio P, et al. Nat Commun. 2016 Mar 24;7:10948. doi: 10.1038/ncomms10948. Nat Commun. 2016. PMID: 27009901 Free PMC article.

8

Aggregation mechanism of an IgG2 and two IgG1 monoclonal antibodies at low pH: from oligomers to larger aggregates.

Arosio P, Rima S, Morbidelli M. Arosio P, et al. Pharm Res. 2013 Mar;30(3):641-54. doi: 10.1007/s11095-012-0885-3. Epub 2012 Oct 9. Pharm Res. 2013. PMID: 23054090

9

A Nanoparticle-Based Assay To Evaluate Surface-Induced Antibody Instability.

Kopp MRG, Capasso Palmiero U, Arosio P. Kopp MRG, et al. Among authors: arosio p. Mol Pharm. 2020 Mar 2;17(3):909-918. doi: 10.1021/acs.molpharmaceut.9b01168. Epub 2020 Jan 27. Mol Pharm. 2020. PMID: 31917582

10

In situ analysis of osmolyte mechanisms of proteome thermal stabilization.

Pepelnjak M, Velten B, Näpflin N, von Rosen T, Palmiero UC, Ko JH, Maynard HD, Arosio P, Weber-Ban E, de Souza N, Huber W, Picotti P. Pepelnjak M, et al. Among authors: arosio p. Nat Chem Biol. 2024 Feb 29. doi: 10.1038/s41589-024-01568-7. Online ahead of print. Nat Chem Biol. 2024. PMID: 38424171

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