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Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.
An S, Kim G, Kim HJ, Ahn S, Kim HY, Ko H, Hyun YE, Nguyen M, Jeong J, Liu Z, Han J, Choi H, Yu J, Kim JW, Lee HW, Jacobson KA, Cho WJ, Kim YM, Kang KW, Noh M, Jeong LS. An S, et al. Among authors: kim hy, kim g, kim hj, kim ym, kim jw. J Med Chem. 2020 Dec 24;63(24):16012-16027. doi: 10.1021/acs.jmedchem.0c01874. Epub 2020 Dec 16. J Med Chem. 2020. PMID: 33325691 Free PMC article.
Structure-Activity Relationships of Truncated 1'-Homologated Carbaadenosine Derivatives as New PPARγ/δ Ligands: A Study on Sugar Puckering Affecting Binding to PPARs.
Hyun YE, An S, Kim M, Park IG, Yoon S, Javaid HMA, Vu TNL, Kim G, Choi H, Lee HW, Noh M, Huh JY, Choi S, Kim HR, Jeong LS. Hyun YE, et al. Among authors: kim g, kim m, kim hr. J Med Chem. 2023 Apr 13;66(7):4961-4978. doi: 10.1021/acs.jmedchem.2c02071. Epub 2023 Mar 26. J Med Chem. 2023. PMID: 36967575
Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.
Yoon JS, Kim G, Jarhad DB, Kim HR, Shin YS, Qu S, Sahu PK, Kim HO, Lee HW, Wang SB, Kong YJ, Chang TS, Ogando NS, Kovacikova K, Snijder EJ, Posthuma CC, van Hemert MJ, Jeong LS. Yoon JS, et al. Among authors: kim g, kim ho, kim hr. J Med Chem. 2019 Jul 11;62(13):6346-6362. doi: 10.1021/acs.jmedchem.9b00781. Epub 2019 Jun 20. J Med Chem. 2019. PMID: 31244113 Free PMC article.
In Silico Discovery of 5'-Modified 7-Deoxy-7-ethynyl-4'-thioadenosine as a HASPIN Inhibitor and Its Synergistic Anticancer Effect with the PLK1 Inhibitor.
Kwon EJ, Mashelkar KK, Seo J, Shin YZ, Sung K, Jang SC, Cheon SW, Lee H, Lee HW, Kim G, Han BW, Lee SK, Jeong LS, Cha HJ. Kwon EJ, et al. Among authors: kim g. ACS Cent Sci. 2023 May 11;9(6):1140-1149. doi: 10.1021/acscentsci.3c00332. eCollection 2023 Jun 28. ACS Cent Sci. 2023. PMID: 37396870 Free PMC article.
Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity.
Kim G, Hou X, Byun WS, Kim G, Jarhad DB, Lee G, Hyun YE, Yu J, Lee CS, Qu S, Warnick E, Gao ZG, Kim JY, Ji S, Shin H, Choi JR, Jacobson KA, Lee HW, Lee SK, Jeong LS. Kim G, et al. Among authors: kim jy. J Med Chem. 2023 Sep 14;66(17):12249-12265. doi: 10.1021/acs.jmedchem.3c00806. Epub 2023 Aug 21. J Med Chem. 2023. PMID: 37603705
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