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Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians.
Luo Y, Suliman S, Asgari S, Amariuta T, Baglaenko Y, Martínez-Bonet M, Ishigaki K, Gutierrez-Arcelus M, Calderon R, Lecca L, León SR, Jimenez J, Yataco R, Contreras C, Galea JT, Becerra M, Nejentsev S, Nigrovic PA, Moody DB, Murray MB, Raychaudhuri S. Luo Y, et al. Among authors: nigrovic pa. Nat Commun. 2019 Aug 21;10(1):3765. doi: 10.1038/s41467-019-11664-1. Nat Commun. 2019. PMID: 31434886 Free PMC article.
Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis.
Julé AM, Hoyt KJ, Wei K, Gutierrez-Arcelus M, Taylor ML, Ng J, Lederer JA, Case SM, Chang MH, Cohen EM, Dedeoglu F, Hazen MM, Hausmann JS, Halyabar O, Janssen E, Lo J, Lo MS, Meidan E, Roberts JE, Son MBF, Sundel RP, Lee PY, Chatila T, Nigrovic PA, Henderson LA. Julé AM, et al. Among authors: nigrovic pa. JCI Insight. 2021 Sep 22;6(18):e149185. doi: 10.1172/jci.insight.149185. JCI Insight. 2021. PMID: 34403374 Free PMC article.
Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant.
Wang Q, Martínez-Bonet M, Kim T, Sparks JA, Ishigaki K, Chen X, Sudman M, Aguiar V, Sim S, Hernandez MC, Chiu DJ, Wactor A, Wauford B, Marion MC, Gutierrez-Arcelus M, Bowes J, Eyre S, Nordal E, Prahalad S, Rygg M, Videm V, Raychaudhuri S, Weirauch MT, Langefeld CD, Thompson SD, Nigrovic PA. Wang Q, et al. Among authors: nigrovic pa. Cell Genom. 2023 Oct 16;3(11):100420. doi: 10.1016/j.xgen.2023.100420. eCollection 2023 Nov 8. Cell Genom. 2023. PMID: 38020975 Free PMC article.
Non-coding autoimmune risk variant defines role for ICOS in T peripheral helper cell development.
Kim T, Martínez-Bonet M, Wang Q, Hackert N, Sparks JA, Baglaenko Y, Koh B, Darbousset R, Laza-Briviesca R, Chen X, Aguiar VRC, Chiu DJ, Westra HJ, Gutierrez-Arcelus M, Weirauch MT, Raychaudhuri S, Rao DA, Nigrovic PA. Kim T, et al. Among authors: nigrovic pa. Nat Commun. 2024 Mar 9;15(1):2150. doi: 10.1038/s41467-024-46457-8. Nat Commun. 2024. PMID: 38459032 Free PMC article.
High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction.
Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra HJ, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA. Li G, et al. Among authors: nigrovic pa. Nat Genet. 2018 Aug;50(8):1180-1188. doi: 10.1038/s41588-018-0159-z. Epub 2018 Jul 16. Nat Genet. 2018. PMID: 30013183 Free PMC article.
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis.
Henderson LA, Hoyt KJ, Lee PY, Rao DA, Jonsson AH, Nguyen JP, Rutherford K, Julé AM, Charbonnier LM, Case S, Chang MH, Cohen EM, Dedeoglu F, Fuhlbrigge RC, Halyabar O, Hazen MM, Janssen E, Kim S, Lo J, Lo MS, Meidan E, Son MBF, Sundel RP, Stoll ML, Nusbaum C, Lederer JA, Chatila TA, Nigrovic PA. Henderson LA, et al. Among authors: nigrovic pa. JCI Insight. 2020 Mar 26;5(6):e132508. doi: 10.1172/jci.insight.132508. JCI Insight. 2020. PMID: 32213704 Free PMC article.
204 results