Thelingwani R - Search Results

1

Investigation of the Differences in the Pharmacokinetics of CYP2D6 Substrates, Desipramine, and Dextromethorphan in Healthy African Subjects Carrying the Allelic Variants CYP2D6*17 and CYP2D6*29, When Compared with Normal Metabolizers.

Marasanapalle VP, Masimirembwa C, Sivasubramanian R, Sayyed S, Weinzierl-Hinum A, Mehta D, Kapungu NN, Kanji C, Thelingwani R, Zack J. Marasanapalle VP, et al. Among authors: thelingwani r. J Clin Pharmacol. 2024 May;64(5):578-589. doi: 10.1002/jcph.2366. Epub 2023 Oct 25. J Clin Pharmacol. 2024. PMID: 37803948

2

In vitro and in silico identification and characterization of thiabendazole as a mechanism-based inhibitor of CYP1A2 and simulation of possible pharmacokinetic drug-drug interactions.

Thelingwani RS, Zvada SP, Dolgos H, Ungell AL, Masimirembwa CM. Thelingwani RS, et al. Drug Metab Dispos. 2009 Jun;37(6):1286-94. doi: 10.1124/dmd.108.024604. Epub 2009 Mar 19. Drug Metab Dispos. 2009. PMID: 19299526

3

Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa.

Thelingwani RS, Dhansay K, Smith P, Chibale K, Masimirembwa CM. Thelingwani RS, et al. Xenobiotica. 2012 Oct;42(10):989-1000. doi: 10.3109/00498254.2012.681077. Epub 2012 Apr 25. Xenobiotica. 2012. PMID: 22533317

4

Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity.

Thelingwani R, Bonn B, Chibale K, Masimirembwa C. Thelingwani R, et al. Expert Opin Drug Metab Toxicol. 2014 Oct;10(10):1313-24. doi: 10.1517/17425255.2014.954547. Expert Opin Drug Metab Toxicol. 2014. PMID: 25219629

5

Evaluation of Herbal Medicines: Value Addition to Traditional Medicines Through Metabolism, Pharmacokinetic and Safety Studies.

Thelingwani R, Masimirembwa C. Thelingwani R, et al. Curr Drug Metab. 2014;15(10):942-52. doi: 10.2174/1389200216666150206125727. Curr Drug Metab. 2014. PMID: 25658125 Review.

6

Characterisation of artemisinin-chloroquinoline hybrids for potential metabolic liabilities.

Thelingwani R, Leandersson C, Bonn B, Smith P, Chibale K, Masimirembwa C. Thelingwani R, et al. Xenobiotica. 2016;46(3):234-40. doi: 10.3109/00498254.2015.1070975. Epub 2015 Sep 4. Xenobiotica. 2016. PMID: 26338168

7

Community burden of undiagnosed HIV infection among adolescents in Zimbabwe following primary healthcare-based provider-initiated HIV testing and counselling: A cross-sectional survey.

Simms V, Dauya E, Dakshina S, Bandason T, McHugh G, Munyati S, Chonzi P, Kranzer K, Ncube G, Masimirembwa C, Thelingwani R, Apollo T, Hayes R, Weiss HA, Ferrand RA. Simms V, et al. Among authors: thelingwani r. PLoS Med. 2017 Jul 25;14(7):e1002360. doi: 10.1371/journal.pmed.1002360. eCollection 2017 Jul. PLoS Med. 2017. PMID: 28742829 Free PMC article.

8

The effect of ketoconazole on praziquantel pharmacokinetics and the role of CYP3A4 in the formation of X-OH-praziquantel and not 4-OH-praziquantel.

Nleya L, Thelingwani R, Li XQ, Cavallin E, Isin E, Nhachi C, Masimirembwa C. Nleya L, et al. Among authors: thelingwani r. Eur J Clin Pharmacol. 2019 Aug;75(8):1077-1087. doi: 10.1007/s00228-019-02663-8. Epub 2019 May 15. Eur J Clin Pharmacol. 2019. PMID: 31089768 Clinical Trial.

9

In vitro and in vivo human metabolism and pharmacokinetics of S- and R-praziquantel.

Kapungu NN, Li X, Nhachi C, Masimirembwa C, Thelingwani RS. Kapungu NN, et al. Pharmacol Res Perspect. 2020 Aug;8(4):e00618. doi: 10.1002/prp2.618. Pharmacol Res Perspect. 2020. PMID: 32700798 Free PMC article. Clinical Trial.

10

Clinically relevant enantiomer specific R- and S-praziquantel pharmacokinetic drug-drug interactions with efavirenz and ritonavir.

Mutiti CS, Kapungu NN, Kanji CR, Stadler N, Stingl J, Nhachi C, Hakim J, Masimirembwa C, Thelingwani RS. Mutiti CS, et al. Pharmacol Res Perspect. 2021 May;9(3):e00769. doi: 10.1002/prp2.769. Pharmacol Res Perspect. 2021. PMID: 33929078 Free PMC article.

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