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Negative DNA supercoiling induces genome-wide Cas9 off-target activity.
Newton MD, Losito M, Smith QM, Parnandi N, Taylor BJ, Akcakaya P, Maresca M, van Eijk P, Reed SH, Boulton SJ, King GA, Cuomo ME, Rueda DS. Newton MD, et al. Mol Cell. 2023 Oct 5;83(19):3533-3545.e5. doi: 10.1016/j.molcel.2023.09.008. Mol Cell. 2023. PMID: 37802026 Free article.
DNA stretching induces Cas9 off-target activity.
Newton MD, Taylor BJ, Driessen RPC, Roos L, Cvetesic N, Allyjaun S, Lenhard B, Cuomo ME, Rueda DS. Newton MD, et al. Nat Struct Mol Biol. 2019 Mar;26(3):185-192. doi: 10.1038/s41594-019-0188-z. Epub 2019 Feb 25. Nat Struct Mol Biol. 2019. PMID: 30804513 Free PMC article.
Cas12a target search and cleavage on force-stretched DNA.
Losito M, Smith QM, Newton MD, Cuomo ME, Rueda DS. Losito M, et al. Among authors: newton md. Phys Chem Chem Phys. 2021 Dec 8;23(47):26640-26644. doi: 10.1039/d1cp03408a. Phys Chem Chem Phys. 2021. PMID: 34494640 Free PMC article.
A Minimal Load-and-Lock RuII Luminescent DNA Probe.
Newton MD, Fairbanks SD, Thomas JA, Rueda DS. Newton MD, et al. Angew Chem Int Ed Engl. 2021 Sep 13;60(38):20952-20959. doi: 10.1002/anie.202108077. Epub 2021 Aug 11. Angew Chem Int Ed Engl. 2021. PMID: 34378843 Free PMC article.
HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51.
Anand R, Buechelmaier E, Belan O, Newton M, Vancevska A, Kaczmarczyk A, Takaki T, Rueda DS, Powell SN, Boulton SJ. Anand R, et al. Nature. 2022 Jan;601(7892):268-273. doi: 10.1038/s41586-021-04261-0. Epub 2021 Dec 22. Nature. 2022. PMID: 34937945 Free PMC article.
77 results