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Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
Saaoud F, Liu L, Xu K, Cueto R, Shao Y, Lu Y, Sun Y, Snyder NW, Wu S, Yang L, Zhou Y, Williams DL, Li C, Martinez L, Vazquez-Padron RI, Zhao H, Jiang X, Wang H, Yang X. Saaoud F, et al. Among authors: snyder nw. JCI Insight. 2023 Jan 10;8(1):e158183. doi: 10.1172/jci.insight.158183. JCI Insight. 2023. PMID: 36394956 Free PMC article.
Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.
Drummer C 4th, Saaoud F, Jhala NC, Cueto R, Sun Y, Xu K, Shao Y, Lu Y, Shen H, Yang L, Zhou Y, Yu J, Wu S, Snyder NW, Hu W, Zhuo J', Zhong Y, Jiang X, Wang H, Yang X. Drummer C 4th, et al. Among authors: snyder nw. Front Immunol. 2023 Jan 26;14:1113883. doi: 10.3389/fimmu.2023.1113883. eCollection 2023. Front Immunol. 2023. PMID: 36776889 Free PMC article.
ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm development.
Lu Y, Sun Y, Saaoud F, Shao Y, Xu K, Jiang X, Wu S, Yu J, Snyder NW, Yang L, Shi XM, Zhao H, Wang H, Yang X. Lu Y, et al. Among authors: snyder nw. Front Immunol. 2023 Sep 4;14:1268916. doi: 10.3389/fimmu.2023.1268916. eCollection 2023. Front Immunol. 2023. PMID: 37731512 Free PMC article.
Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy.
Flam E, Jang C, Murashige D, Yang Y, Morley MP, Jung S, Kantner DS, Pepper H, Bedi KC Jr, Brandimarto J, Prosser BL, Cappola T, Snyder NW, Rabinowitz JD, Margulies KB, Arany Z. Flam E, et al. Among authors: snyder nw. Nat Cardiovasc Res. 2022 Sep;1(9):817-829. doi: 10.1038/s44161-022-00117-6. Epub 2022 Aug 29. Nat Cardiovasc Res. 2022. PMID: 36776621 Free PMC article.
Acetate controls endothelial-to-mesenchymal transition.
Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M. Zhu X, et al. Among authors: snyder nw. Cell Metab. 2023 Jul 11;35(7):1163-1178.e10. doi: 10.1016/j.cmet.2023.05.010. Epub 2023 Jun 15. Cell Metab. 2023. PMID: 37327791
Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells.
Esquea EM, Ciraku L, Young RG, Merzy J, Talarico AN, Ahmed NN, Karuppiah M, Ramesh A, Chatoff A, Crispim CV, Rashad AA, Cocklin S, Snyder NW, Beld J, Simone NL, Reginato MJ, Dick A. Esquea EM, et al. Among authors: snyder nw. Front Pharmacol. 2024 May 16;15:1394685. doi: 10.3389/fphar.2024.1394685. eCollection 2024. Front Pharmacol. 2024. PMID: 38818373 Free PMC article.
ATM inhibition drives metabolic adaptation via induction of macropinocytosis.
Huang Z, Chen CW, Buj R, Tangudu NK, Fang RS, Leon KE, Dahl ES, Varner EL, von Krusenstiern E, Cole AR, Snyder NW, Aird KM. Huang Z, et al. Among authors: snyder nw. J Cell Biol. 2023 Jan 2;222(1):e202007026. doi: 10.1083/jcb.202007026. Epub 2022 Nov 18. J Cell Biol. 2023. PMID: 36399181 Free PMC article.
134 results