Qin X - Search Results

1

The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib.

Chen S, Li X, Li Y, He X, Bryant M, Qin X, Li F, Seo JE, Guo X, Mei N, Guo L. Chen S, et al. Among authors: qin x. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099. Toxicol Sci. 2023. PMID: 37788138 Free PMC article.

2

Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice.

Qin X, Hakenjos JM, MacKenzie KR, Barzi M, Chavan H, Nyshadham P, Wang J, Jung SY, Guner JZ, Chen S, Guo L, Krishnamurthy P, Bissig KD, Palmer S, Matzuk MM, Li F. Qin X, et al. Drug Metab Dispos. 2022 Feb;50(2):128-139. doi: 10.1124/dmd.121.000633. Epub 2021 Nov 16. Drug Metab Dispos. 2022. PMID: 34785568 Free PMC article.

3

Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline.

Ren Z, Chen S, Qin X, Li F, Guo L. Ren Z, et al. Among authors: qin x. Arch Toxicol. 2022 Dec;96(12):3219-3231. doi: 10.1007/s00204-022-03369-0. Epub 2022 Sep 9. Arch Toxicol. 2022. PMID: 36083301 Free PMC article.

4

The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice.

Qin X, Xie C, Hakenjos JM, MacKenzie KR, Boyd SR, Barzi M, Bissig KD, Young DW, Li F. Qin X, et al. Eur J Pharm Sci. 2023 Feb 1;181:106358. doi: 10.1016/j.ejps.2022.106358. Epub 2022 Dec 10. Eur J Pharm Sci. 2023. PMID: 36513193 Free PMC article.

5

Effects of apical sodium-bile acid transporter inhibitor and obeticholic acid co-treatment in experimental non-alcoholic steatohepatitis.

Matye DJ, Qin X, Hasan MN, Gu L, Clayton YD, Li F, Li T. Matye DJ, et al. Among authors: qin x. Liver Res. 2022 Dec;6(4):276-283. doi: 10.1016/j.livres.2022.11.002. Epub 2022 Nov 13. Liver Res. 2022. PMID: 36819659 Free PMC article.

6

Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC-MS-Based Metabolomic Approaches.

Qin X, Wang Y, MacKenzie KR, Hakenjos JM, Chen S, Khalil SM, Jung SY, Young DW, Guo L, Li F. Qin X, et al. Chem Res Toxicol. 2023 Aug 21;36(8):1427-1438. doi: 10.1021/acs.chemrestox.3c00164. Epub 2023 Aug 2. Chem Res Toxicol. 2023. PMID: 37531179 Free PMC article.

7

Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model.

Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu L. Padilla J, et al. Among authors: qin x. J Hepatol. 2024 Feb;80(2):282-292. doi: 10.1016/j.jhep.2023.10.018. Epub 2023 Oct 27. J Hepatol. 2024. PMID: 37890720

8

Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library.

Park S, Fan J, Chamakuri S, Palaniappan M, Sharma K, Qin X, Wang J, Tan Z, Judge A, Hu L, Sankaran B, Li F, Prasad BVV, Matzuk MM, Palzkill T. Park S, et al. Among authors: qin x. J Med Chem. 2024 Jan 11;67(1):620-642. doi: 10.1021/acs.jmedchem.3c01834. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117688

9

CYP3A Mediates an Unusual C(sp²)-C(sp³) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism.

Qin X, Wang Y, Ye Q, Hakenjos JM, Wang J, Teng M, Guo L, Tan Z, Young DW, MacKenzie KR, Li F. Qin X, et al. Angew Chem Int Ed Engl. 2024 Jun 3;63(23):e202405197. doi: 10.1002/anie.202405197. Epub 2024 Apr 29. Angew Chem Int Ed Engl. 2024. PMID: 38574245 Free PMC article.

10

MALDI imaging mass spectrometry visualizes the distribution of antidepressant duloxetine and its major metabolites in mouse brain, liver, kidney, and spleen tissues.

Khalil SM, Qin X, Hakenjos JM, Wang J, Hu Z, Liu X, Wang J, Maletic-Savatic M, MacKenzie KR, Matzuk MM, Li F. Khalil SM, et al. Among authors: qin x. Drug Metab Dispos. 2024 Apr 24:DMD-AR-2024-001719. doi: 10.1124/dmd.124.001719. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38658163 Free article.

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