Gupta G - Search Results

1

Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.

Shell DJ, Foley CA, Wang Q, Smith CM, Guduru SKR, Zeng H, Dong A, Norris-Drouin JL, Axtman M, Hardy PB, Gupta G, Halabelian L, Frye SV, James LI, Pearce KH. Shell DJ, et al. Among authors: gupta g. J Med Chem. 2023 Oct 26;66(20):14133-14149. doi: 10.1021/acs.jmedchem.3c01192. Epub 2023 Oct 2. J Med Chem. 2023. PMID: 37782247 Free PMC article.

2

Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks.

Feng W, Simpson DA, Cho JE, Carvajal-Garcia J, Smith CM, Headley KM, Hathaway N, Ramsden DA, Gupta GP. Feng W, et al. Nucleic Acids Res. 2021 May 21;49(9):5095-5105. doi: 10.1093/nar/gkab299. Nucleic Acids Res. 2021. PMID: 33963863 Free PMC article.

3

Spatially Localized Immunotherapy: A Perfect Combination With Radiation Therapy?

Wang Q, Gupta GP. Wang Q, et al. Int J Radiat Oncol Biol Phys. 2021 Jun 1;110(2):507-509. doi: 10.1016/j.ijrobp.2021.02.046. Int J Radiat Oncol Biol Phys. 2021. PMID: 33989577 No abstract available.

4

Targeting Non-homologous and Alternative End Joining Repair to Enhance Cancer Radiosensitivity.

Feng W, Smith CM, Simpson DA, Gupta GP. Feng W, et al. Semin Radiat Oncol. 2022 Jan;32(1):29-41. doi: 10.1016/j.semradonc.2021.09.007. Semin Radiat Oncol. 2022. PMID: 34861993 Review.

5

Polymerase θ inhibition steps on the cGAS pedal.

Smith CM, Gupta GP. Smith CM, et al. J Clin Invest. 2023 Jun 1;133(11):e170660. doi: 10.1172/JCI170660. J Clin Invest. 2023. PMID: 37259920 Free PMC article.

6

MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.

Cho MG, Kumar RJ, Lin CC, Boyer JA, Shahir JA, Fagan-Solis K, Simpson DA, Fan C, Foster CE, Goddard AM, Lerner LM, Ellington SW, Wang Q, Wang Y, Ho AY, Liu P, Perou CM, Zhang Q, McGinty RK, Purvis JE, Gupta GP. Cho MG, et al. Nature. 2024 Jan;625(7995):585-592. doi: 10.1038/s41586-023-06889-6. Epub 2024 Jan 10. Nature. 2024. PMID: 38200309 Free PMC article.

7

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.

Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, Testa JR, Nussenzweig A, Gupta GP, Sykes SM, Johnson N. Nacson J, et al. Cell Rep. 2018 Sep 25;24(13):3513-3527.e7. doi: 10.1016/j.celrep.2018.08.086. Cell Rep. 2018. PMID: 30257212 Free PMC article.

8

Mechanism, cellular functions and cancer roles of polymerase-theta-mediated DNA end joining.

Ramsden DA, Carvajal-Garcia J, Gupta GP. Ramsden DA, et al. Nat Rev Mol Cell Biol. 2022 Feb;23(2):125-140. doi: 10.1038/s41580-021-00405-2. Epub 2021 Sep 14. Nat Rev Mol Cell Biol. 2022. PMID: 34522048 Review.

9

Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection.

Luedeman ME, Stroik S, Feng W, Luthman AJ, Gupta GP, Ramsden DA. Luedeman ME, et al. Nat Commun. 2022 Aug 4;13(1):4547. doi: 10.1038/s41467-022-32166-7. Nat Commun. 2022. PMID: 35927262 Free PMC article.

10

Calibration of cell-free DNA measurements by next-generation sequencing.

Hoerres D, Dai Q, Elmore S, Sheth S, Gupta GP, Kumar S, Gulley ML. Hoerres D, et al. Am J Clin Pathol. 2023 Sep 1;160(3):314-321. doi: 10.1093/ajcp/aqad055. Am J Clin Pathol. 2023. PMID: 37244060 Free PMC article.

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