Malcolm T - Search Results

1

Differential membrane binding of α/β-peptide foldamers: implications for cellular delivery and mitochondrial targeting.

Lee TH, Checco JW, Malcolm T, Eller CH, Raines RT, Gellman SH, Lee EF, Fairlie WD, Aguilar MI. Lee TH, et al. Among authors: malcolm t. Aust J Chem. 2023 Aug;76(8):482-492. doi: 10.1071/ch23063. Epub 2023 Jun 14. Aust J Chem. 2023. PMID: 37780415 Free PMC article.

2

Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases.

Vinh NB, Drinkwater N, Malcolm TR, Kassiou M, Lucantoni L, Grin PM, Butler GS, Duffy S, Overall CM, Avery VM, Scammells PJ, McGowan S. Vinh NB, et al. J Med Chem. 2019 Jan 24;62(2):622-640. doi: 10.1021/acs.jmedchem.8b01310. Epub 2019 Jan 4. J Med Chem. 2019. PMID: 30537832

3

A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.

Webb CT, Yang W, Riley BT, Hayes BK, Sivaraman KK, Malcolm TR, Harrop S, Atkinson SC, Kass I, Buckle AM, Drinkwater N, McGowan S. Webb CT, et al. Among authors: malcolm tr. J Biol Chem. 2022 Jul;298(7):102119. doi: 10.1016/j.jbc.2022.102119. Epub 2022 Jun 9. J Biol Chem. 2022. PMID: 35691342 Free PMC article.

4

Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.

Calic PPS, Vinh NB, Webb CT, Malcolm TR, Ngo A, Lowes K, Drinkwater N, McGowan S, Scammells PJ. Calic PPS, et al. Among authors: malcolm tr. Eur J Med Chem. 2023 Feb 15;248:115051. doi: 10.1016/j.ejmech.2022.115051. Epub 2022 Dec 29. Eur J Med Chem. 2023. PMID: 36634455

5

Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.

Malcolm TR, Belousoff MJ, Venugopal H, Borg NA, Drinkwater N, Atkinson SC, McGowan S. Malcolm TR, et al. J Biol Chem. 2021 Jan-Jun;296:100173. doi: 10.1074/jbc.RA120.016313. Epub 2020 Dec 17. J Biol Chem. 2021. PMID: 33303633 Free PMC article.

6

Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV.

Anderson AJ, Crameri JJ, Ang CS, Malcolm TR, Kang Y, Baker MJ, Palmer CS, Sharpe AJ, Formosa LE, Ganio K, Baker MJ, McDevitt CA, Ryan MT, Maher MJ, Stojanovski D. Anderson AJ, et al. Among authors: malcolm tr. EMBO Rep. 2023 Aug 3;24(8):e56430. doi: 10.15252/embr.202256430. Epub 2023 Jun 5. EMBO Rep. 2023. PMID: 37272231 Free article.

7

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases.

Malcolm TR, Swiderska KW, Hayes BK, Webb CT, Drag M, Drinkwater N, McGowan S. Malcolm TR, et al. Biochem J. 2021 Jul 16;478(13):2697-2713. doi: 10.1042/BCJ20210172. Biochem J. 2021. PMID: 34133730 Free PMC article.

8

M17 aminopeptidases diversify function by moderating their macromolecular assemblies and active site environment.

Drinkwater N, Malcolm TR, McGowan S. Drinkwater N, et al. Biochimie. 2019 Nov;166:38-51. doi: 10.1016/j.biochi.2019.01.007. Epub 2019 Jan 14. Biochimie. 2019. PMID: 30654132 Review.

9

M1 aminopeptidases as drug targets: broad applications or therapeutic niche?

Drinkwater N, Lee J, Yang W, Malcolm TR, McGowan S. Drinkwater N, et al. FEBS J. 2017 May;284(10):1473-1488. doi: 10.1111/febs.14009. Epub 2017 Feb 3. FEBS J. 2017. PMID: 28075056 Free PMC article. Review.

10

Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway.

Edgar RCS, Siddiqui G, Hjerrild K, Malcolm TR, Vinh NB, Webb CT, Holmes C, MacRaild CA, Chernih HC, Suen WW, Counihan NA, Creek DJ, Scammells PJ, McGowan S, de Koning-Ward TF. Edgar RCS, et al. Among authors: malcolm tr. Elife. 2022 Sep 13;11:e80813. doi: 10.7554/eLife.80813. Elife. 2022. PMID: 36097817 Free PMC article.

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