Kostrubsky V - Search Results

1

Preclinical safety, toxicokinetics and metabolism of BIIB131, a novel prothrombolytic agent for acute stroke.

Kostrubsky V, Liu Y, Muste C, Gu C, Kirkland M, Nishimura N, Hasegawa K, Hasumi K, Yuan L. Kostrubsky V, et al. Regul Toxicol Pharmacol. 2023 Dec;145:105498. doi: 10.1016/j.yrtph.2023.105498. Epub 2023 Sep 29. Regul Toxicol Pharmacol. 2023. PMID: 37778433

2

Development and Application of a Liquid Chromatography-Mass Spectrometry Method for Residual Iodixanol Quantification in AAV-Based Gene Therapy Product Development.

Pu Y, Katz R, Chen Y, Kostrubsky V, Clarner P, Lo SC, Sosic Z, Yeung B. Pu Y, et al. Among authors: kostrubsky v. Hum Gene Ther. 2022 Jan;33(1-2):103-108. doi: 10.1089/hum.2021.136. Epub 2021 Sep 20. Hum Gene Ther. 2022. PMID: 34376063 Free PMC article.

3

In vitro effects of ethanol and mouthrinse on permeability in an oral buccal mucosal tissue construct.

Koschier F, Kostrubsky V, Toole C, Gallo MA. Koschier F, et al. Among authors: kostrubsky v. Food Chem Toxicol. 2011 Oct;49(10):2524-9. doi: 10.1016/j.fct.2011.06.018. Epub 2011 Jun 21. Food Chem Toxicol. 2011. PMID: 21712062

4

Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

Feng B, Xu JJ, Bi YA, Mireles R, Davidson R, Duignan DB, Campbell S, Kostrubsky VE, Dunn MC, Smith AR, Wang HF. Feng B, et al. Among authors: kostrubsky ve. Toxicol Sci. 2009 Apr;108(2):492-500. doi: 10.1093/toxsci/kfp033. Epub 2009 Feb 17. Toxicol Sci. 2009. PMID: 19223659

5

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.

Wolf KK, Wood SG, Allard JL, Hunt JA, Gorman N, Walton-Strong BW, Szakacs JG, Duan SX, Hao Q, Court MH, von Moltke LL, Greenblatt DJ, Kostrubsky V, Jeffery EH, Wrighton SA, Gonzalez FJ, Sinclair PR, Sinclair JF. Wolf KK, et al. Among authors: kostrubsky v. Drug Metab Dispos. 2007 Jul;35(7):1223-31. doi: 10.1124/dmd.107.014738. Epub 2007 Mar 28. Drug Metab Dispos. 2007. PMID: 17392391

6

Hepatobiliary disposition in primary cultures of dog and monkey hepatocytes.

Rose KA, Kostrubsky V, Sahi J. Rose KA, et al. Among authors: kostrubsky v. Mol Pharm. 2006 May-Jun;3(3):266-74. doi: 10.1021/mp0501022. Mol Pharm. 2006. PMID: 16749858

7

Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.

Yohe HC, O'Hara KA, Hunt JA, Kitzmiller TJ, Wood SG, Bement JL, Bement WJ, Szakacs JG, Wrighton SA, Jacobs JM, Kostrubsky V, Sinclair PR, Sinclair JF. Yohe HC, et al. Among authors: kostrubsky v. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1269-79. doi: 10.1152/ajpgi.00239.2005. Epub 2006 Jan 26. Am J Physiol Gastrointest Liver Physiol. 2006. PMID: 16439473 Free article.

8

Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.

Noreault TL, Kostrubsky VE, Wood SG, Nichols RC, Strom SC, Trask HW, Wrighton SA, Evans RM, Jacobs JM, Sinclair PR, Sinclair JF. Noreault TL, et al. Among authors: kostrubsky ve. Drug Metab Dispos. 2005 Jul;33(7):993-1003. doi: 10.1124/dmd.105.003954. Epub 2005 Apr 15. Drug Metab Dispos. 2005. PMID: 15833926

9

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats.

Kostrubsky VE, Strom SC, Hanson J, Urda E, Rose K, Burliegh J, Zocharski P, Cai H, Sinclair JF, Sahi J. Kostrubsky VE, et al. Toxicol Sci. 2003 Nov;76(1):220-8. doi: 10.1093/toxsci/kfg217. Epub 2003 Aug 27. Toxicol Sci. 2003. PMID: 12944587

10

Agree that idiosyncratic hepatotoxicity in TRO-treated patients is uncertain, but concerned about the data.

Kostrubsky VE, Rahbari R, Lodola A, Davies T. Kostrubsky VE, et al. Toxicol Sci. 2003 Feb;71(2):282; author reply 282-4. doi: 10.1093/toxsci/71.2.282. Toxicol Sci. 2003. PMID: 12563115 No abstract available.

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