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Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.
Perfetti MT, Baughman BM, Dickson BM, Mu Y, Cui G, Mader P, Dong A, Norris JL, Rothbart SB, Strahl BD, Brown PJ, Janzen WP, Arrowsmith CH, Mer G, McBride KM, James LI, Frye SV. Perfetti MT, et al. Among authors: james li. ACS Chem Biol. 2015 Apr 17;10(4):1072-81. doi: 10.1021/cb500956g. Epub 2015 Jan 28. ACS Chem Biol. 2015. PMID: 25590533 Free PMC article.
Targeting chromatin readers.
James LI, Frye SV. James LI, et al. Clin Pharmacol Ther. 2013 Apr;93(4):312-4. doi: 10.1038/clpt.2013.6. Epub 2013 Jan 17. Clin Pharmacol Ther. 2013. PMID: 23403847 Free PMC article. Review.
The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer.
Baughman BM, Pattenden SG, Norris JL, James LI, Frye SV. Baughman BM, et al. Among authors: james li. ACS Chem Biol. 2016 Mar 18;11(3):722-8. doi: 10.1021/acschembio.5b00632. Epub 2015 Sep 2. ACS Chem Biol. 2016. PMID: 26317848 Free PMC article. Retracted.
Target class drug discovery.
Barnash KD, James LI, Frye SV. Barnash KD, et al. Among authors: james li. Nat Chem Biol. 2017 Sep 19;13(10):1053-1056. doi: 10.1038/nchembio.2473. Nat Chem Biol. 2017. PMID: 28926557 Free PMC article.
Chemical probes for methyl lysine reader domains.
James LI, Frye SV. James LI, et al. Curr Opin Chem Biol. 2016 Aug;33:135-41. doi: 10.1016/j.cbpa.2016.06.004. Epub 2016 Jun 25. Curr Opin Chem Biol. 2016. PMID: 27348158 Free PMC article. Review.
Structural basis of paralog-specific KDM2A/B nucleosome recognition.
Spangler CJ, Skrajna A, Foley CA, Nguyen A, Budziszewski GR, Azzam DN, Arteaga EC, Simmons HC, Smith CB, Wesley NA, Wilkerson EM, McPherson JE, Kireev D, James LI, Frye SV, Goldfarb D, McGinty RK. Spangler CJ, et al. Among authors: james li. Nat Chem Biol. 2023 May;19(5):624-632. doi: 10.1038/s41589-023-01256-y. Epub 2023 Feb 16. Nat Chem Biol. 2023. PMID: 36797403 Free PMC article.
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen.
Shell DJ, Foley CA, Wang Q, Smith CM, Guduru SKR, Zeng H, Dong A, Norris-Drouin JL, Axtman M, Hardy PB, Gupta G, Halabelian L, Frye SV, James LI, Pearce KH. Shell DJ, et al. Among authors: james li. J Med Chem. 2023 Oct 26;66(20):14133-14149. doi: 10.1021/acs.jmedchem.3c01192. Epub 2023 Oct 2. J Med Chem. 2023. PMID: 37782247 Free PMC article.
449 results