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Page 1
Tuning ultrasmall theranostic nanoparticles for MRI contrast and radiation dose amplification.
Brown N, Rocchi P, Carmès L, Guthier R, Iyer M, Seban L, Morris T, Bennett S, Lavelle M, Penailillo J, Carrasco R, Williams C, Huynh E, Han Z, Kaza E, Doussineau T, Toprani SM, Qin X, Nagel ZD, Sarosiek KA, Hagège A, Dufort S, Bort G, Lux F, Tillement O, Berbeco R. Brown N, et al. Among authors: sarosiek ka. Theranostics. 2023 Aug 21;13(14):4711-4729. doi: 10.7150/thno.85663. eCollection 2023. Theranostics. 2023. PMID: 37771768 Free PMC article.
Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX.
Singh R, Yu S, Osman M, Inde Z, Fraser C, Cleveland AH, Almanzar N, Lim CB, Joshi GN, Spetz J, Qin X, Toprani SM, Nagel Z, Hocking MC, Cormack RA, Yock TI, Miller JW, Yuan ZM, Gershon T, Sarosiek KA. Singh R, et al. Among authors: sarosiek ka. Cancer Res. 2023 Oct 13;83(20):3442-3461. doi: 10.1158/0008-5472.CAN-22-1337. Cancer Res. 2023. PMID: 37470810 Free PMC article.
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
Montero J, Sarosiek KA, DeAngelo JD, Maertens O, Ryan J, Ercan D, Piao H, Horowitz NS, Berkowitz RS, Matulonis U, Jänne PA, Amrein PC, Cichowski K, Drapkin R, Letai A. Montero J, et al. Among authors: sarosiek ka. Cell. 2015 Feb 26;160(5):977-989. doi: 10.1016/j.cell.2015.01.042. Cell. 2015. PMID: 25723171 Free PMC article.
Small molecule SJ572946 activates BAK to initiate apoptosis.
Sekar G, Singh G, Qin X, Guibao CD, Schwam B, Inde Z, Grace CR, Zhang W, Slavish PJ, Lin W, Chen T, Lee RE, Rankovic Z, Sarosiek K, Moldoveanu T. Sekar G, et al. iScience. 2022 Sep 6;25(10):105064. doi: 10.1016/j.isci.2022.105064. eCollection 2022 Oct 21. iScience. 2022. PMID: 36147946 Free PMC article.
Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics.
Fraser CS, Spetz JKE, Qin X, Presser A, Choiniere J, Li C, Yu S, Blevins F, Hata AN, Miller JW, Bradshaw GA, Kalocsay M, Sanchorawala V, Sarosiek S, Sarosiek KA. Fraser CS, et al. Among authors: sarosiek s, sarosiek ka. Nat Commun. 2022 Oct 2;13(1):5789. doi: 10.1038/s41467-022-33461-z. Nat Commun. 2022. PMID: 36184661 Free PMC article.
Targeting Galectin 3 illuminates its contributions to the pathology of uterine serous carcinoma.
Matoba Y, Zarrella DT, Pooladanda V, Azimi Mohammadabadi M, Kim E, Kumar S, Xu M, Qin X, Ray LJ, Devins KM, Kumar R, Kononenko A, Eisenhauer E, Veillard IE, Yamagami W, Hill SJ, Sarosiek KA, Yeku OO, Spriggs DR, Rueda BR. Matoba Y, et al. Among authors: sarosiek ka. Br J Cancer. 2024 May;130(9):1463-1476. doi: 10.1038/s41416-024-02621-x. Epub 2024 Mar 4. Br J Cancer. 2024. PMID: 38438589 Free PMC article.
Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
Hata AN, Yeo A, Faber AC, Lifshits E, Chen Z, Cheng KA, Walton Z, Sarosiek KA, Letai A, Heist RS, Mino-Kenudson M, Wong KK, Engelman JA. Hata AN, et al. Among authors: sarosiek ka. Cancer Res. 2014 Jun 1;74(11):3146-56. doi: 10.1158/0008-5472.CAN-13-3728. Epub 2014 Mar 27. Cancer Res. 2014. PMID: 24675361 Free PMC article.
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. McBrayer SK, et al. Among authors: sarosiek ka. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13. Cell. 2018. PMID: 30220459 Free PMC article.
60 results