Zhang D - Search Results

1

The Importance of Tracking "Missing" Metabolites: How and Why?

Wang S, Ballard TE, Christopher LJ, Foti RS, Gu C, Khojasteh SC, Liu J, Ma S, Ma B, Obach RS, Schadt S, Zhang Z, Zhang D. Wang S, et al. Among authors: zhang d, zhang z. J Med Chem. 2023 Dec 14;66(23):15586-15612. doi: 10.1021/acs.jmedchem.3c01293. Epub 2023 Sep 28. J Med Chem. 2023. PMID: 37769129 Review.

2

Cyp2D6 catalyzes 5-hydroxylation of 1-(2-pyrimidinyl)-piperazine, an active metabolite of several psychoactive drugs, in human liver microsomes.

Raghavan N, Zhang D, Zhu M, Zeng J, Christopher L. Raghavan N, et al. Among authors: zhang d. Drug Metab Dispos. 2005 Feb;33(2):203-8. doi: 10.1124/dmd.104.001198. Epub 2004 Oct 26. Drug Metab Dispos. 2005. PMID: 15507542

3

Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys.

Christopher LJ, Cui D, Li W, Barros A Jr, Arora VK, Zhang H, Wang L, Zhang D, Manning JA, He K, Fletcher AM, Ogan M, Lago M, Bonacorsi SJ, Humphreys WG, Iyer RA. Christopher LJ, et al. Among authors: zhang d, zhang h. Drug Metab Dispos. 2008 Jul;36(7):1341-56. doi: 10.1124/dmd.107.018234. Epub 2008 Apr 17. Drug Metab Dispos. 2008. PMID: 18420785

4

Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics.

Wang L, Christopher LJ, Cui D, Li W, Iyer R, Humphreys WG, Zhang D. Wang L, et al. Among authors: zhang d. Drug Metab Dispos. 2008 Sep;36(9):1828-39. doi: 10.1124/dmd.107.020255. Epub 2008 Jun 12. Drug Metab Dispos. 2008. PMID: 18556438

5

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.

Fan PW, Zhang D, Halladay JS, Driscoll JP, Khojasteh SC. Fan PW, et al. Among authors: zhang d. Drug Metab Dispos. 2016 Aug;44(8):1253-61. doi: 10.1124/dmd.116.070169. Epub 2016 Apr 26. Drug Metab Dispos. 2016. PMID: 27117704 Review.

6

Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates.

Zhang D, Yu SF, Ma Y, Xu K, Dragovich PS, Pillow TH, Liu L, Del Rosario G, He J, Pei Z, Sadowsky JD, Erickson HK, Hop CE, Khojasteh SC. Zhang D, et al. Drug Metab Dispos. 2016 Sep;44(9):1517-23. doi: 10.1124/dmd.116.070631. Epub 2016 Jul 14. Drug Metab Dispos. 2016. PMID: 27417182 Free PMC article.

7

Non-cytochrome P450-mediated bioactivation and its toxicological relevance.

Gan J, Ma S, Zhang D. Gan J, et al. Among authors: zhang d. Drug Metab Rev. 2016 Nov;48(4):473-501. doi: 10.1080/03602532.2016.1225756. Epub 2016 Sep 20. Drug Metab Rev. 2016. PMID: 27533622 Review.

8

Antibody Drug Conjugates Differentiate Uptake and DNA Alkylation of Pyrrolobenzodiazepines in Tumors from Organs of Xenograft Mice.

Ma Y, Khojasteh SC, Hop CE, Erickson HK, Polson A, Pillow TH, Yu SF, Wang H, Dragovich PS, Zhang D. Ma Y, et al. Among authors: zhang d. Drug Metab Dispos. 2016 Dec;44(12):1958-1962. doi: 10.1124/dmd.116.073031. Epub 2016 Sep 28. Drug Metab Dispos. 2016. PMID: 27683653

9

Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.

Zhang D, Pillow TH, Ma Y, Cruz-Chuh JD, Kozak KR, Sadowsky JD, Lewis Phillips GD, Guo J, Darwish M, Fan P, Chen J, He C, Wang T, Yao H, Xu Z, Chen J, Wai J, Pei Z, Hop CE, Khojasteh SC, Dragovich PS. Zhang D, et al. ACS Med Chem Lett. 2016 Aug 26;7(11):988-993. doi: 10.1021/acsmedchemlett.6b00233. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882196 Free PMC article.

10

Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8).

Ma Y, Fu Y, Khojasteh SC, Dalvie D, Zhang D. Ma Y, et al. Among authors: zhang d. J Med Chem. 2017 Nov 9;60(21):8691-8705. doi: 10.1021/acs.jmedchem.7b00510. Epub 2017 Jun 27. J Med Chem. 2017. PMID: 28653847 Review.

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