Schadt S - Search Results

1

The Importance of Tracking "Missing" Metabolites: How and Why?

Wang S, Ballard TE, Christopher LJ, Foti RS, Gu C, Khojasteh SC, Liu J, Ma S, Ma B, Obach RS, Schadt S, Zhang Z, Zhang D. Wang S, et al. Among authors: schadt s. J Med Chem. 2023 Dec 14;66(23):15586-15612. doi: 10.1021/acs.jmedchem.3c01293. Epub 2023 Sep 28. J Med Chem. 2023. PMID: 37769129 Review.

2

A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.

Schadt S, Bister B, Chowdhury SK, Funk C, Hop CECA, Humphreys WG, Igarashi F, James AD, Kagan M, Khojasteh SC, Nedderman ANR, Prakash C, Runge F, Scheible H, Spracklin DK, Swart P, Tse S, Yuan J, Obach RS. Schadt S, et al. Drug Metab Dispos. 2018 Jun;46(6):865-878. doi: 10.1124/dmd.117.079848. Epub 2018 Feb 27. Drug Metab Dispos. 2018. PMID: 29487142 Review.

3

Identification of GalNAc-Conjugated Antisense Oligonucleotide Metabolites Using an Untargeted and Generic Approach Based on High Resolution Mass Spectrometry.

Husser C, Brink A, Zell M, Müller MB, Koller E, Schadt S. Husser C, et al. Among authors: schadt s. Anal Chem. 2017 Jun 20;89(12):6821-6826. doi: 10.1021/acs.analchem.7b01244. Epub 2017 May 25. Anal Chem. 2017. PMID: 28520401

4

Genotoxicity Assessment of Drug Metabolites in the Context of MIST and Beyond.

Zeller A, Brigo A, Brink A, Guerard M, Lang D, Muster W, Runge F, Sutter A, Vock E, Wichard J, Schadt S. Zeller A, et al. Among authors: schadt s. Chem Res Toxicol. 2020 Jan 21;33(1):10-19. doi: 10.1021/acs.chemrestox.9b00348. Epub 2020 Jan 9. Chem Res Toxicol. 2020. PMID: 31859487

5

Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate.

Husser C, Pähler A, Seymour M, Kuhlmann O, Schadt S, Zell M. Husser C, et al. Among authors: schadt s. J Pharm Biomed Anal. 2018 Apr 15;152:143-154. doi: 10.1016/j.jpba.2018.01.022. Epub 2018 Jan 12. J Pharm Biomed Anal. 2018. PMID: 29414006

6

In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.

Zell M, Husser C, Staack RF, Jordan G, Richter WF, Schadt S, Pähler A. Zell M, et al. Among authors: schadt s. Anal Chem. 2016 Dec 6;88(23):11670-11677. doi: 10.1021/acs.analchem.6b03252. Epub 2016 Nov 18. Anal Chem. 2016. PMID: 27934109

7

Application of Imaging Techniques to Cases of Drug-Induced Crystal Nephropathy in Preclinical Studies.

Lenz B, Brink A, Siam M, De Paepe A, Bassett S, Eichinger-Chapelon A, Maliver P, Neff R, Niederhauser U, Steinhuber B, Zurbach R, Singer T, Funk C, Schuler F, Albassam M, Schadt S. Lenz B, et al. Among authors: schadt s. Toxicol Sci. 2018 Jun 1;163(2):409-419. doi: 10.1093/toxsci/kfx044. Toxicol Sci. 2018. PMID: 28329870

8

Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design.

Brink A, Pähler A, Funk C, Schuler F, Schadt S. Brink A, et al. Among authors: schadt s. Drug Discov Today. 2017 May;22(5):751-756. doi: 10.1016/j.drudis.2016.11.018. Epub 2016 Nov 27. Drug Discov Today. 2017. PMID: 27903430

9

Evaluation of relative LC/MS response of metabolites to parent drug in LC/nanospray ionization mass spectrometry: potential implications in MIST assessment.

Schadt S, Chen LZ, Bischoff D. Schadt S, et al. J Mass Spectrom. 2011 Dec;46(12):1281-6. doi: 10.1002/jms.2018. J Mass Spectrom. 2011. PMID: 22223420

10

Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.

Schadt S, Hauri S, Lopes F, Edelmann MR, Staack RF, Villaseñor R, Kettenberger H, Roth AB, Schuler F, Richter WF, Funk C. Schadt S, et al. Drug Metab Dispos. 2019 Dec;47(12):1443-1456. doi: 10.1124/dmd.119.088997. Drug Metab Dispos. 2019. PMID: 31748266

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