Ma S - Search Results

1

The Importance of Tracking "Missing" Metabolites: How and Why?

Wang S, Ballard TE, Christopher LJ, Foti RS, Gu C, Khojasteh SC, Liu J, Ma S, Ma B, Obach RS, Schadt S, Zhang Z, Zhang D. Wang S, et al. Among authors: ma b, ma s. J Med Chem. 2023 Dec 14;66(23):15586-15612. doi: 10.1021/acs.jmedchem.3c01293. Epub 2023 Sep 28. J Med Chem. 2023. PMID: 37769129 Review.

2

Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in Glucuronidation.

Wang S, Ma S, Chen E, Wang J, Le H, Hanlon SP, Binder M, Lee W, Khojasteh SC, Salphati L. Wang S, et al. Among authors: ma s. Drug Metab Dispos. 2023 Jul;51(7):862-872. doi: 10.1124/dmd.123.001289. Epub 2023 Apr 14. Drug Metab Dispos. 2023. PMID: 37059472

3

Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor.

Takahashi RH, Ma S, Robinson SJ, Yue Q, Choo EF, Khojasteh SC. Takahashi RH, et al. Among authors: ma s. Drug Metab Dispos. 2015 Dec;43(12):1929-33. doi: 10.1124/dmd.115.067181. Epub 2015 Oct 5. Drug Metab Dispos. 2015. PMID: 26438627

4

Preclinical Characterization of the Distribution, Catabolism, and Elimination of a Polatuzumab Vedotin-Piiq (POLIVY^®) Antibody-Drug Conjugate in Sprague Dawley Rats.

Yip V, Lee MV, Saad OM, Ma S, Khojasteh SC, Shen BQ. Yip V, et al. Among authors: ma s. J Clin Med. 2021 Mar 23;10(6):1323. doi: 10.3390/jcm10061323. J Clin Med. 2021. PMID: 33806916 Free PMC article.

5

Non-cytochrome P450-mediated bioactivation and its toxicological relevance.

Gan J, Ma S, Zhang D. Gan J, et al. Among authors: ma s. Drug Metab Rev. 2016 Nov;48(4):473-501. doi: 10.1080/03602532.2016.1225756. Epub 2016 Sep 20. Drug Metab Rev. 2016. PMID: 27533622 Review.

6

Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.

Takahashi RH, Halladay JS, Siu M, Chen Y, Hop CE, Khojasteh SC, Ma S. Takahashi RH, et al. Among authors: ma s. Drug Metab Dispos. 2017 May;45(5):430-440. doi: 10.1124/dmd.116.074336. Epub 2017 Feb 10. Drug Metab Dispos. 2017. PMID: 28188299

7

CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339.

Takahashi RH, Wang X, Segraves NL, Wang J, Chang JH, Khojasteh SC, Ma S. Takahashi RH, et al. Among authors: ma s. Drug Metab Dispos. 2017 Oct;45(10):1084-1092. doi: 10.1124/dmd.117.076786. Epub 2017 Aug 8. Drug Metab Dispos. 2017. PMID: 28790146

8

Strategies to Mitigate the Bioactivation of Aryl Amines.

Zhang C, Crawford JJ, Landry ML, Chen H, Kenny JR, Khojasteh SC, Lee W, Ma S, Young WB. Zhang C, et al. Among authors: ma s. Chem Res Toxicol. 2020 Jul 20;33(7):1950-1959. doi: 10.1021/acs.chemrestox.0c00138. Epub 2020 Jun 23. Chem Res Toxicol. 2020. PMID: 32508087

9

Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti-Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats.

Cai H, Yip V, Lee MV, Wong S, Saad O, Ma S, Ljumanovic N, Khojasteh SC, Kamath AV, Shen BQ. Cai H, et al. Among authors: ma s. Drug Metab Dispos. 2020 Nov;48(11):1161-1168. doi: 10.1124/dmd.120.000092. Epub 2020 Aug 24. Drug Metab Dispos. 2020. PMID: 32839277

10

Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats.

Takahashi R, Ma S, Deese A, Yue Q, Kim-Kang H, Yi Y, Siu M, Hunt KW, Kallan NC, Hop CE, Liu X, Khojasteh SC. Takahashi R, et al. Among authors: ma s. Drug Metab Dispos. 2014 May;42(5):890-8. doi: 10.1124/dmd.114.057141. Epub 2014 Mar 4. Drug Metab Dispos. 2014. PMID: 24595682

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